(1S,2S,5S,6R)-2,5-Dichloro-3,4-bis-(4-chloro-phenyl)-8-oxo-6-trifluoromethyl-7-oxa-tricyclo[4.2.2.0^2,5]deca-3,9-diene-9-carboxylic acid methyl ester

Base Information

• Chemical Name: (1S,2S,5S,6R)-2,5-Dichloro-3,4-bis-(4-chloro-phenyl)-8-oxo-6-trifluoromethyl-7-oxa-tricyclo[4.2.2.0^2,5]deca-3,9-diene-9-carboxylic acid methyl ester
• CAS No.: 101660-30-4
• Molecular Formula: C₂₄H₁₃Cl₄F₃O₄
• Molecular Weight: 564.172

Synonyms:

Chemical Property of (1S,2S,5S,6R)-2,5-Dichloro-3,4-bis-(4-chloro-phenyl)-8-oxo-6-trifluoromethyl-7-oxa-tricyclo[4.2.2.0^2,5]deca-3,9-diene-9-carboxylic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1S,2S,5S,6R)-2,5-Dichloro-3,4-bis-(4-chloro-phenyl)-8-oxo-6-trifluoromethyl-7-oxa-tricyclo[4.2.2.0^2,5]deca-3,9-diene-9-carboxylic acid methyl ester

There total 4 articles about (1S,2S,5S,6R)-2,5-Dichloro-3,4-bis-(4-chloro-phenyl)-8-oxo-6-trifluoromethyl-7-oxa-tricyclo[4.2.2.0^2,5]deca-3,9-diene-9-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

1-chloro-4-(chloroethynyl)benzene (33491-02-0) + methyl 2-oxo-6-(trifluoromethyl)-2H-pyran-4-carboxylate (101640-70-4) → (1S,2S,5S,6R)-2,5-Dichloro-3,4-bis-(4-chloro-phenyl)-8-oxo-6-trifluoromethyl-7-oxa-tricyclo[4.2.2.02,5]deca-3,9-diene-9-carboxylic acid methyl ester (101660-30-4)

Guidance literature:

at 140 ℃;

DOI:10.1016/S0040-4039(00)98694-5

Reference yield:

Dimethyl itakonate (617-52-7) → (1S,2S,5S,6R)-2,5-Dichloro-3,4-bis-(4-chloro-phenyl)-8-oxo-6-trifluoromethyl-7-oxa-tricyclo[4.2.2.02,5]deca-3,9-diene-9-carboxylic acid methyl ester (101660-30-4)

Guidance literature:

Multi-step reaction with 4 steps

1: 57 percent / CuCl / 8 h / 140 °C

2: triethylamine / toluene

3: 62 percent / hydroquinone / CuCl / 1,3,5-trimethyl-benzene

4: 70 percent / 140 °C

With triethylamine; hydroquinone; copper(l) chloride; In toluene; 1,3,5-trimethyl-benzene;

DOI:10.1016/S0040-4039(00)98694-5

Reference yield:

methyl-3-methoxycarbonyl-3,5,5-trichloro-6,6,6-trifluorohexanoate (101640-67-9) → (1S,2S,5S,6R)-2,5-Dichloro-3,4-bis-(4-chloro-phenyl)-8-oxo-6-trifluoromethyl-7-oxa-tricyclo[4.2.2.02,5]deca-3,9-diene-9-carboxylic acid methyl ester (101660-30-4)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / toluene

2: 62 percent / hydroquinone / CuCl / 1,3,5-trimethyl-benzene

3: 70 percent / 140 °C

With triethylamine; hydroquinone; copper(l) chloride; In toluene; 1,3,5-trimethyl-benzene;

DOI:10.1016/S0040-4039(00)98694-5

upstream raw materials:

1-chloro-4-(chloroethynyl)benzene

methyl 2-oxo-6-(trifluoromethyl)-2H-pyran-4-carboxylate

Dimethyl itakonate

methyl-3-methoxycarbonyl-3,5,5-trichloro-6,6,6-trifluorohexanoate

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