Technology Process of 6-<<(hydroxyimino)phenyl>methyl>-1-<(1-methylethyl)sulfonyl>-1H-imidazo<4,5-b>pyridin-2-amine
There total 6 articles about 6-<<(hydroxyimino)phenyl>methyl>-1-<(1-methylethyl)sulfonyl>-1H-imidazo<4,5-b>pyridin-2-amine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 1.) PCl5 2.) AlCl3 / 1.a) 7 h, reflux b) 18 h, r.t. 2.) 1.5 h, reflux
2: 83 percent / aq. NH4OH / methanol / 2.5 h / Heating
3: H2 / platinum oxide / aq. ethanol / 0.67 h / 1034.3 - 2585.7 Torr
4: 1.) triethylamine 2.) dicyclohexylcarbodiimide / 1.) acetonitrile, 10 min 2.) 2 h, reflux
5: 38 percent / 4M aq. NaOH / 2 h / steam bath
6: 31 percent / K2CO3 / dimethylformamide / 2.5 h
7: hydroxyl amine hydrochloride, pyridine / methanol / 4 h / Heating
With
pyridine; ammonium hydroxide; sodium hydroxide; aluminium trichloride; phosphorus pentachloride; hydroxylamine hydrochloride; hydrogen; potassium carbonate; triethylamine; dicyclohexyl-carbodiimide;
platinum(IV) oxide;
In
methanol; ethanol; N,N-dimethyl-formamide;
DOI:10.1002/jhet.5570270656
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 1.) PCl5 2.) AlCl3 / 1.a) 7 h, reflux b) 18 h, r.t. 2.) 1.5 h, reflux
2: 83 percent / aq. NH4OH / methanol / 2.5 h / Heating
3: H2 / platinum oxide / aq. ethanol / 0.67 h / 1034.3 - 2585.7 Torr
4: 1.) triethylamine 2.) dicyclohexylcarbodiimide / 1.) acetonitrile, 10 min 2.) 2 h, reflux
5: 38 percent / 4M aq. NaOH / 2 h / steam bath
6: 31 percent / K2CO3 / dimethylformamide / 2.5 h
7: hydroxyl amine hydrochloride, pyridine / methanol / 4 h / Heating
With
pyridine; ammonium hydroxide; sodium hydroxide; aluminium trichloride; phosphorus pentachloride; hydroxylamine hydrochloride; hydrogen; potassium carbonate; triethylamine; dicyclohexyl-carbodiimide;
platinum(IV) oxide;
In
methanol; ethanol; N,N-dimethyl-formamide;
DOI:10.1002/jhet.5570270656
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1.) triethylamine 2.) dicyclohexylcarbodiimide / 1.) acetonitrile, 10 min 2.) 2 h, reflux
2: 38 percent / 4M aq. NaOH / 2 h / steam bath
3: 31 percent / K2CO3 / dimethylformamide / 2.5 h
4: hydroxyl amine hydrochloride, pyridine / methanol / 4 h / Heating
With
pyridine; sodium hydroxide; hydroxylamine hydrochloride; potassium carbonate; triethylamine; dicyclohexyl-carbodiimide;
In
methanol; N,N-dimethyl-formamide;
DOI:10.1002/jhet.5570270656
