6635-31-0

Basic information

• Product Name: 6-Hydroxy-5-nitronicotinic acid
• Synonyms: 5-CARBOXY-3-NITRO-2(1H)-PYRIDINONE;6-HYDROXY-5-NITRONICOTINIC ACID;2-HYDROXY-3-NITRO-5-PYRIDINECARBOXYLIC ACID;2-HYDROXY-3-NITROPYRIDINE-5-CARBOXYLIC ACID;6-Hydroxy-5-nitronicotinic acid 97%;6-hyroxy-5-nitronicotinic acid;6-Hydroxy-5-nitropyridine-3-carboxylic acid, 5-Carboxy-2-hydroxy-3-nitropyridine
• CAS NO: 6635-31-0
• Molecular Formula: C₆H₄N₂O₅
• Molecular Weight: 184.11
• Product Categories: blocks;Carboxes;NitroCompounds;Pyridines;CHIRAL CHEMICALS
• Mol File: 6635-31-0.mol
• Article Data: 14

Chemical Properties

• Melting Point: 269-271
• Boiling Point: 463.434 °C at 760 mmHg
• Flash Point: 234.076 °C
• Appearance: /
• Density: 1.746 g/cm³
• Storage Temp.: Keep Cold
• PKA: 3.09±0.50(Predicted)
• BRN: 177986
• CAS DataBase Reference: 6-Hydroxy-5-nitronicotinic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Hydroxy-5-nitronicotinic acid(6635-31-0)
• EPA Substance Registry System: 6-Hydroxy-5-nitronicotinic acid(6635-31-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37
• Safety Statements: 26
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 6635-31-0(Hazardous Substances Data)

Usage

General Description

6-Hydroxy-5-nitronicotinic acid is a chemical compound typically used in research and scientific studies. As the name suggests, it is a derivative of nicotinic acid, which is also known as vitamin B3 or niacin. The compound features a hydroxy group and a nitro group added to the nicotinic acid structure, which significantly alters the chemical properties of the compound. Its potential uses or roles are not well defined in literature, suggesting that it is mostly relevant in specific research contexts. Safety and toxicity data is not widely available, further indicating that it is primarily used in controlled experimental settings.

Upstream product

• 5006-66-6 6-hydroxy-3-pyridinecarboxylic acid 
• 23056-40-8 2-chloro-5-methyl-3-nitro-pyridine 

Downstream Products

• 222970-61-8 5-carbomethoxy-3-nitro-1H-pyridin-2-one 
• 222970-60-7 3-amino-5-carbomethoxy-1H-pyridin-2-one 
• 23945-84-8 6-chloro-5-nitro-nicotinoyl chloride 
• 7477-10-3 6-chloro-5-nitronicotinic acid 
• 59237-53-5 methyl 6-chloro-5-nitro-pyridine-3-carboxylate 

Relevant articles and documents

A 6-hydroxy-5-nitro-nicotinic acid synthetic method and its separating and purifying method

The invention discloses a synthetic method and a separation purification method of 6-hydroxyl-5-nitro niacin and belongs to the field of fine chemical engineering. According to the method, 6-hydroxyl niacin is used as a raw material and is subjected to pre-nitration reaction under the action of concentrated sulfuric acid, concentrated nitric acid and a catalyst ammonium bisulfate, nitration reaction, crystal separation purification and the like to obtain highly purified 6- hydroxyl-5-nitro niacin to meet purity requirements on midbody by pharmaceutical synthetic fields. The synthetic method has the advantages of being simple in synthetic process, mild in condition, high in yield, high in purity of obtained product, easy to operate and the like and is suitable for industrial production.

NOVEL COMPOUND, PRODUCTION METHOD THEREFOR, AND APPLICATION THEREFOR

[Problems] To provide a novel peptide synthesis technique that is completely different than heretofore, and to provide a novel compound that enables the synthesis/creation of a novel artificial functional protein and the synthesis/creation of a novel functional peptide, as well as a method for producing the same. [Solution] A compound represented by formula (I) or a salt thereof.

Development of a solid-supported biotinylation reagent for efficient biotin labeling of SH groups on small molecules

We report here the design and synthesis of a novel and selective SH-group biotinylating reagent, KSH-1 (1), for the biotinylation of small molecules using solid phase chemistry. The results demonstrate that 1 efficiently biotinylated a small molecule, cap