4-Methoxy-1-oxido-2-picolyl phenyl [9-(3`-O-tert-butyldiphenylsilyl-2`,5`,6`-trideoxy-β-D-erythro-hexofuranosyl)-2-N-isobutyrylguanin-6`-yl]phosphonate

Base Information

Chemical Name:4-Methoxy-1-oxido-2-picolyl phenyl [9-(3`-O-tert-butyldiphenylsilyl-2`,5`,6`-trideoxy-β-D-erythro-hexofuranosyl)-2-N-isobutyrylguanin-6`-yl]phosphonate
CAS No.:250650-32-9
Molecular Formula:C₄₄H₅₁N₆O₉PSi
Molecular Weight:866.983
Hs Code.:

4-Methoxy-1-oxido-2-picolyl phenyl [9-(3`-O-tert-butyldiphenylsilyl-2`,5`,6`-trideoxy-β-D-erythro-hexofuranosyl)-2-N-isobutyrylguanin-6`-yl]phosphonate

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Chemical Property of 4-Methoxy-1-oxido-2-picolyl phenyl [9-(3`-O-tert-butyldiphenylsilyl-2`,5`,6`-trideoxy-β-D-erythro-hexofuranosyl)-2-N-isobutyrylguanin-6`-yl]phosphonate

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Technology Process of 4-Methoxy-1-oxido-2-picolyl phenyl [9-(3`-O-tert-butyldiphenylsilyl-2`,5`,6`-trideoxy-β-D-erythro-hexofuranosyl)-2-N-isobutyrylguanin-6`-yl]phosphonate

There total 6 articles about 4-Methoxy-1-oxido-2-picolyl phenyl [9-(3`-O-tert-butyldiphenylsilyl-2`,5`,6`-trideoxy-β-D-erythro-hexofuranosyl)-2-N-isobutyrylguanin-6`-yl]phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 64364-95-0
4-methoxy-1-oxido-2-pyridylmethanol

: Phenyl[9-(3`-O-tert-butyldiphenylsilyl-2`,5`,6`-trideoxy-β-D-erythro-hexofuranosyl)-2-N-isobutyrylguanin-6`-yl]phosphonate, triethylammonium salt

: 250650-32-9
4-Methoxy-1-oxido-2-picolyl phenyl [9-(3`-O-tert-butyldiphenylsilyl-2`,5`,6`-trideoxy-β-D-erythro-hexofuranosyl)-2-N-isobutyrylguanin-6`-yl]phosphonate

Guidance literature:: With pyridine; 4-methoxypyridine N-oxide; 2-chloro-5,5-dimethyl[1,3,2]dioxaphosphinane 2-oxide; for 1h;
DOI:10.1039/a906066i

Reference yield:

: 22400-41-5
diphenyl [(triphenylphosphoranylidene)methyl]phosphonate

: 250650-32-9
4-Methoxy-1-oxido-2-picolyl phenyl [9-(3`-O-tert-butyldiphenylsilyl-2`,5`,6`-trideoxy-β-D-erythro-hexofuranosyl)-2-N-isobutyrylguanin-6`-yl]phosphonate

Guidance literature:: Multi-step reaction with 4 steps

1: dimethylsulfoxide / 7 h

2: 71 percent / potassium azodicarboxylate / pyridine; acetic acid

3: 78 percent / Pyridine-2-aldoxime; 1,1,3,3-tetramethylguanidine / H₂O; dioxane / 12 h

4: 95 percent / 2-chloro-5,5-dimethyl-2-oxo-2λ⁵-1,3,2-dioxaphosphinane; 4-methoxypyridine N-oxide; pyridine / 1 h

With pyridine; 4-methoxypyridine N-oxide; 2-hydroxyiminomethyl-pyridine; 2-chloro-5,5-dimethyl[1,3,2]dioxaphosphinane 2-oxide; potassium diazodicarboxylate; N,N,N',N'-tetramethylguanidine; In 1,4-dioxane; pyridine; water; acetic acid; dimethyl sulfoxide; 1: Condensation / 2: Reduction / 3: Hydrolysis / 4: Condensation;
DOI:10.1039/a906066i

Reference yield:

: 114745-19-6
2-N-isobutyryl-3'-O-tert-butyldiphenylsilyl-2'-deoxyguanosine

: 250650-32-9
4-Methoxy-1-oxido-2-picolyl phenyl [9-(3`-O-tert-butyldiphenylsilyl-2`,5`,6`-trideoxy-β-D-erythro-hexofuranosyl)-2-N-isobutyrylguanin-6`-yl]phosphonate

Guidance literature:: Multi-step reaction with 5 steps

1: 1,3-dicyclohexylcarbodiimide; pyridine; CF₃COOH / dimethylsulfoxide

2: dimethylsulfoxide / 7 h

3: 71 percent / potassium azodicarboxylate / pyridine; acetic acid

4: 78 percent / Pyridine-2-aldoxime; 1,1,3,3-tetramethylguanidine / H₂O; dioxane / 12 h

5: 95 percent / 2-chloro-5,5-dimethyl-2-oxo-2λ⁵-1,3,2-dioxaphosphinane; 4-methoxypyridine N-oxide; pyridine / 1 h

With pyridine; 4-methoxypyridine N-oxide; 2-hydroxyiminomethyl-pyridine; 2-chloro-5,5-dimethyl[1,3,2]dioxaphosphinane 2-oxide; potassium diazodicarboxylate; dicyclohexyl-carbodiimide; trifluoroacetic acid; N,N,N',N'-tetramethylguanidine; In 1,4-dioxane; pyridine; water; acetic acid; dimethyl sulfoxide; 1: Oxidation / 2: Condensation / 3: Reduction / 4: Hydrolysis / 5: Condensation;
DOI:10.1039/a906066i