diethyl 2,2'-{[(4-{[4-(dimethylamino)phenyl]ethynyl}-6-{[(2-methoxy-2-oxoethyl)(methyl)amino]methyl}pyridin-2-yl)methyl]azanediyl}diacetate

Base Information

• Chemical Name: diethyl 2,2'-{[(4-{[4-(dimethylamino)phenyl]ethynyl}-6-{[(2-methoxy-2-oxoethyl)(methyl)amino]methyl}pyridin-2-yl)methyl]azanediyl}diacetate
• CAS No.: 1609476-23-4
• Molecular Formula: C₂₉H₃₈N₄O₆
• Molecular Weight: 538.644
• Mol file: 1609476-23-4.mol

Synonyms:

Chemical Property of diethyl 2,2'-{[(4-{[4-(dimethylamino)phenyl]ethynyl}-6-{[(2-methoxy-2-oxoethyl)(methyl)amino]methyl}pyridin-2-yl)methyl]azanediyl}diacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of diethyl 2,2'-{[(4-{[4-(dimethylamino)phenyl]ethynyl}-6-{[(2-methoxy-2-oxoethyl)(methyl)amino]methyl}pyridin-2-yl)methyl]azanediyl}diacetate

There total 4 articles about diethyl 2,2'-{[(4-{[4-(dimethylamino)phenyl]ethynyl}-6-{[(2-methoxy-2-oxoethyl)(methyl)amino]methyl}pyridin-2-yl)methyl]azanediyl}diacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

diethyl 2,2'-{[(4-bromo-6-{[(2-methoxy-2-oxoethyl)(methyl)amino]methyl}pyridin-2-yl)methyl]azanediyl}diacetate (1609476-22-3) + 4-ethynyl-N,N-dimethylaniline (17573-94-3,752235-18-0) → diethyl 2,2'-{[(4-{[4-(dimethylamino)phenyl]ethynyl}-6-{[(2-methoxy-2-oxoethyl)(methyl)amino]methyl}pyridin-2-yl)methyl]azanediyl}diacetate (1609476-23-4)

Guidance literature:

With copper(l) iodide; trans-bis(triphenylphosphine)palladium dichloride; triethylamine; In tetrahydrofuran; at 54 ℃; Inert atmosphere;

DOI:10.1002/chem.201304942

Reference yield:

diethyl 2,2'-(((4-bromo-6-(bromomethyl)pyridin-2-yl)methyl)azanediyl)diacetate (1444764-51-5) → diethyl 2,2'-{[(4-{[4-(dimethylamino)phenyl]ethynyl}-6-{[(2-methoxy-2-oxoethyl)(methyl)amino]methyl}pyridin-2-yl)methyl]azanediyl}diacetate (1609476-23-4)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / acetonitrile / 20 h / Reflux

2: triethylamine; trans-bis(triphenylphosphine)palladium dichloride; copper(l) iodide / tetrahydrofuran / 54 °C / Inert atmosphere

With copper(l) iodide; trans-bis(triphenylphosphine)palladium dichloride; potassium carbonate; triethylamine; In tetrahydrofuran; acetonitrile;

DOI:10.1002/chem.201304942

Reference yield:

Diethyl iminodiacetate (6290-05-7) → diethyl 2,2'-{[(4-{[4-(dimethylamino)phenyl]ethynyl}-6-{[(2-methoxy-2-oxoethyl)(methyl)amino]methyl}pyridin-2-yl)methyl]azanediyl}diacetate (1609476-23-4)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / acetonitrile / 3 h / 50 - 60 °C

2: potassium carbonate / acetonitrile / 20 h / Reflux

3: triethylamine; trans-bis(triphenylphosphine)palladium dichloride; copper(l) iodide / tetrahydrofuran / 54 °C / Inert atmosphere

With copper(l) iodide; trans-bis(triphenylphosphine)palladium dichloride; potassium carbonate; triethylamine; In tetrahydrofuran; acetonitrile;

DOI:10.1002/chem.201304942

upstream raw materials:

Diethyl iminodiacetate

diethyl 2,2'-{[(4-bromo-6-{[(2-methoxy-2-oxoethyl)(methyl)amino]methyl}pyridin-2-yl)methyl]azanediyl}diacetate

4-ethynyl-N,N-dimethylaniline

4-bromo-2,6-bis(bromomethyl)pyridine

Downstream raw materials:

europium(III)-2,2'-(((6-(((carboxymethyl)(methyl)amino)methyl)-4-((4-(dimethylamino)phenyl)ethynyl)pyridin-2-yl)methyl)azanediyl)diacetic acid