(1-(4-Chloro-benzoyl)-5-methoxy-2-{4-[3-(4-phenyl-piperazin-1-yl)-propoxy]-phenyl}-1H-indol-3-yl)-acetic acid; hydrochloride

Base Information

• Chemical Name: (1-(4-Chloro-benzoyl)-5-methoxy-2-{4-[3-(4-phenyl-piperazin-1-yl)-propoxy]-phenyl}-1H-indol-3-yl)-acetic acid; hydrochloride
• CAS No.: 134858-68-7
• Molecular Formula: C₃₇H₃₆ClN₃O₅*ClH
• Molecular Weight: 674.624
• Mol file: 134858-68-7.mol

Synonyms:

Chemical Property of (1-(4-Chloro-benzoyl)-5-methoxy-2-{4-[3-(4-phenyl-piperazin-1-yl)-propoxy]-phenyl}-1H-indol-3-yl)-acetic acid; hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1-(4-Chloro-benzoyl)-5-methoxy-2-{4-[3-(4-phenyl-piperazin-1-yl)-propoxy]-phenyl}-1H-indol-3-yl)-acetic acid; hydrochloride

There total 2 articles about (1-(4-Chloro-benzoyl)-5-methoxy-2-{4-[3-(4-phenyl-piperazin-1-yl)-propoxy]-phenyl}-1H-indol-3-yl)-acetic acid; hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

N1-(4-chlorobenzoyl)-4-methoxyphenylhydrazine (16390-07-1) + 1-<4-(2-carboxyethyl)phenoxy>-3-1-(N4-phenyl-piperazinyl)>propane (134858-58-5) → (1-(4-Chloro-benzoyl)-5-methoxy-2-{4-[3-(4-phenyl-piperazin-1-yl)-propoxy]-phenyl}-1H-indol-3-yl)-acetic acid; hydrochloride (134858-68-7)

Guidance literature:

With hydrogenchloride; acetic acid; at 80 ℃; for 6h;

Reference yield:

3-(4-hydroxybenzoyl)propionic acid (56872-39-0) → (1-(4-Chloro-benzoyl)-5-methoxy-2-{4-[3-(4-phenyl-piperazin-1-yl)-propoxy]-phenyl}-1H-indol-3-yl)-acetic acid; hydrochloride (134858-68-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 29 percent / NaOH / ethanol / 8 h / Heating

2: 56 percent / glacial acetic acid, HCl / 6 h / 80 °C

With hydrogenchloride; sodium hydroxide; acetic acid; In ethanol;

upstream raw materials:

N¹-(4-chlorobenzoyl)-4-methoxyphenylhydrazine

1-<4-(2-carboxyethyl)phenoxy>-3-1-(N⁴-phenyl-piperazinyl)>propane

3-(4-hydroxybenzoyl)propionic acid