56872-39-0

Basic information

• Product Name: 4-(4-hydroxyphenyl)-4-oxobutanoic acid
• CAS NO: 56872-39-0
• Molecular Formula: C₁₀H₁₀O₄
• Molecular Weight: 194.184
• Mol File: 56872-39-0.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 460.8°C at 760 mmHg
• Flash Point: 246.6°C
• Density: 1.32g/cm³
• Vapor Pressure: 2.75E-09mmHg at 25°C
• Refractive Index: 1.58
• CAS DataBase Reference: 4-(4-hydroxyphenyl)-4-oxobutanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-hydroxyphenyl)-4-oxobutanoic acid(56872-39-0)
• EPA Substance Registry System: 4-(4-hydroxyphenyl)-4-oxobutanoic acid(56872-39-0)

Safety Data

• Hazardous Substances Data: 56872-39-0(Hazardous Substances Data)

Upstream product

• 7446-70-0 aluminium trichloride 
• 6311-68-8 monophenyl succinate 
• 108-88-3 toluene 
• 15118-67-9 ethyl 3-(4-methoxybenzoyl)-propionate 
• 24849-48-7 4-hydroxybenzoylacrylic acid 
• 33527-94-5 4-acetoxyiodobenzene 
• 113425-33-5 4-hydroxy-1-(4-hydroxyphenyl)-butan-1-one 
• 540-38-5 p-Iodophenol 
• 100-66-3 methoxybenzene 
• 108-95-2 phenol 
• 3153-44-4 4-(4-methoxy-phenyl)-4-oxo-butyric acid 
• 860426-16-0 succinic acid ethyl ester-phenyl ester 
• 7182-43-6 4-(4-hydroxy-phenyl)-4-oxo-butyronitrile 
• 108-30-5 succinic acid anhydride 

Downstream Products

• 855233-95-3 5-(4-acetoxy-phenyl)-3H-furan-2-one 
• 7021-11-6 4-(4-hydroxyphenyl)butanoic acid 
• 66123-43-1 4-(4-hydroxyphenyl)-4-oxobutanoic acid ethyl ester 
• 39560-32-2 4-hydroxy-gamma-oxobenzenebutanoic acid,methyl ester 
• 14328-06-4 5-(4-hydroxyphenyl)-γ-butyrolactone 
• 91121-67-4 4-(4-Isopropoxy-phenyl)-4-oxo-butyric acid 
• 119348-33-3 4-<4-<(4-acetyl-3-hydroxy-2-propylphenyl)methoxy>phenyl>-4-oxobutanoic acid ethyl ether 
• 119348-34-4 4-<4-<(4-acetyl-3-hydroxy-2-propylphenyl)methoxy>phenyl>-4-oxobutanoic acid 
• 134858-68-7 (1-(4-Chloro-benzoyl)-5-methoxy-2-{4-[3-(4-phenyl-piperazin-1-yl)-propoxy]-phenyl}-1H-indol-3-yl)-acetic acid; hydrochloride 
• 91584-73-5 (4S,5R)-5-{4-[3-(4-Acetyl-3-hydroxy-2-propyl-phenoxy)-propylsulfanyl]-phenyl}-4-methyl-dihydro-furan-2-one 
• 91584-73-5 (4R,5R)-5-{4-[3-(4-Acetyl-3-hydroxy-2-propyl-phenoxy)-propylsulfanyl]-phenyl}-4-methyl-dihydro-furan-2-one 
• 108960-40-3 (4S,5R)-5-(4-Mercapto-phenyl)-4-methyl-dihydro-furan-2-one 
• 108960-40-3 (4R,5R)-5-(4-Mercapto-phenyl)-4-methyl-dihydro-furan-2-one 

Relevant articles and documents

Preparation of aromatic γ-hydroxyketones by means of Heck coupling of aryl halides and 2,3-dihydrofuran, catalyzed by a palladium(ii) glycine complex under microwave irradiation

A series of aromatic γ-hydroxyketones were prepared by means of Heck coupling reaction of aryl halides and 2,3-dihydrofuran, catalyzed by PdCl2·Gly2 and under microwave irradiation. This synthetic transformation involves the formation of an aryl-dihydrofuranoic intermediate, followed by an unusual opening of the heterocycle promoted by a water molecule and the formation of the ketone carbonyl function through keto-enol tautomerism. This journal is

PIPERAZINE DERIVATIVES, METHODS FOR PREPARING SAME, AND USES THEREOF IN THE TREATMENT OF INSULIN RESISTANCE

The invention relates to a compound of formula (I), where R1, R2, R7, m, n, and L1 are as defined in claim 1, and to the methods for preparing same, to the pharmaceutical compositions containing same, and to the

Antileukotrienic phenethylamido derivatives of arylalkanoic acids in the treatment of ulcerative colitis

A series of arylalkanoic acid derivatives bearing methyl(phenethyl)amino groups were prepared and their inhibition of LTB4 biosynthesis was evaluated. Regression analysis showed the slightly different parabolic dependences of this activity on lipophilicity of α-methyl and α-unsubstituted alkanoic acid derivatives. The relationship derived for α-unsubstituted alkanoic acids was extended by previously prepared group of similar derivatives of arylacetic acids without any change of regression coefficients and statistical criteria. It was concluded that the most active compounds belong to 2-arylpropanoic acid derivatives with lipophilicity close to log Popt (=6.97). But generally, the structural changes in the acidic part of compounds under study did not yield the substantial improvement of LTB4 biosynthesis inhibition in comparison with the previously prepared series of derivatives IV. The anti-inflammatory effect of the compounds under study was evaluated in three animal models of inflammation and their possible utilization in the treatment of ulcerative colitis (UC) was followed. From 12 evaluated compounds, 4 compounds are more active in UC inhibition than the standard sulfasalazine but it can be stated that the change of connecting chain between aromatic ring and carboxyl did not bring about the important improvement of this activity in comparison with previous derivatives of arylacetic acids. Possible relation between LTB4 biosynthesis inhibition and ulcerative colitis is seriously broken by the compound 8a with carbonyl as the additional functional group on the connecting chain between carboxyl and aromatic ring.