4-Oxazolecarboxylic acid, 2-[[6-[5-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-2-methyl-1,3-pentadien yl]-2-(2,4,6-trimethylphenyl)-1,3-dioxan-4-yl]methyl]-, methyl ester

Base Information

Chemical Name:4-Oxazolecarboxylic acid, 2-[[6-[5-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-2-methyl-1,3-pentadien yl]-2-(2,4,6-trimethylphenyl)-1,3-dioxan-4-yl]methyl]-, methyl ester
CAS No.:105183-57-1
Molecular Formula:C33H34N2O7
Molecular Weight:570.642
Hs Code.:
Mol file:105183-57-1.mol

4-Oxazolecarboxylic acid,
2-[[6-[5-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-2-methyl-1,3-pentadien
yl]-2-(2,4,6-trimethylphenyl)-1,3-dioxan-4-yl]methyl]-, methyl ester

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-Oxazolecarboxylic acid, 2-[[6-[5-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-2-methyl-1,3-pentadien yl]-2-(2,4,6-trimethylphenyl)-1,3-dioxan-4-yl]methyl]-, methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 4-Oxazolecarboxylic acid, 2-[[6-[5-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-2-methyl-1,3-pentadien yl]-2-(2,4,6-trimethylphenyl)-1,3-dioxan-4-yl]methyl]-, methyl ester

There total 10 articles about 4-Oxazolecarboxylic acid, 2-[[6-[5-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-2-methyl-1,3-pentadien yl]-2-(2,4,6-trimethylphenyl)-1,3-dioxan-4-yl]methyl]-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 5044-52-0
vinyltriphenylphosphonium bromide

: 1074-82-4
potassium phtalimide

: 105228-55-5
2-[(4R,6S)-6-((E)-2-Methyl-3-oxo-propenyl)-2-(2,4,6-trimethyl-phenyl)-[1,3]dioxan-4-ylmethyl]-oxazole-4-carboxylic acid methyl ester

: 105183-57-1
2-[(4R,6S)-6-[(1E,3E)-5-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-2-methyl-penta-1,3-dienyl]-2-(2,4,6-trimethyl-phenyl)-[1,3]dioxan-4-ylmethyl]-oxazole-4-carboxylic acid methyl ester

Guidance literature:: In tetrahydrofuran; at 65 ℃; for 48h; Heating;
DOI:10.1021/ja954312r

Reference yield: 51.0%

: 1883-19-8
vinyltri-n-butylphosphonium bromide

: 1074-82-4
potassium phtalimide

: 105228-55-5
2-[(4R,6S)-6-((E)-2-Methyl-3-oxo-propenyl)-2-(2,4,6-trimethyl-phenyl)-[1,3]dioxan-4-ylmethyl]-oxazole-4-carboxylic acid methyl ester

: 105183-57-1
2-[(4R,6S)-6-[(1E,3E)-5-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-2-methyl-penta-1,3-dienyl]-2-(2,4,6-trimethyl-phenyl)-[1,3]dioxan-4-ylmethyl]-oxazole-4-carboxylic acid methyl ester

Guidance literature:: In tetrahydrofuran; for 50h; Heating;
DOI:10.1021/jo00376a011

Reference yield:

: 105228-53-3
2-[(4R,6S)-6-Hydroxymethyl-2-(2,4,6-trimethyl-phenyl)-[1,3]dioxan-4-ylmethyl]-oxazole-4-carboxylic acid methyl ester

: 105183-57-1
2-[(4R,6S)-6-[(1E,3E)-5-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-2-methyl-penta-1,3-dienyl]-2-(2,4,6-trimethyl-phenyl)-[1,3]dioxan-4-ylmethyl]-oxazole-4-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 86 percent / SO₃*pyridine, Et₃N / dimethylsulfoxide

2: 82 percent / benzene / 23 h / Heating

3: 61 percent / tetrahydrofuran / 48 h / 65 °C / Heating

With pyridine-SO₃ complex; triethylamine; In tetrahydrofuran; dimethyl sulfoxide; benzene;
DOI:10.1021/ja954312r