(6R)-3-methyl-8-oxo-7t-(2-phenoxy-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carbothioic acid S-(3-nitro-pyridin-2-yl) ester

Base Information

• Chemical Name: (6R)-3-methyl-8-oxo-7t-(2-phenoxy-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carbothioic acid S-(3-nitro-pyridin-2-yl) ester
• CAS No.: 68206-41-7
• Molecular Formula: C₂₁H₁₈N₄O₆S₂
• Molecular Weight: 486.529
• Mol file: 68206-41-7.mol

Synonyms:

Chemical Property of (6R)-3-methyl-8-oxo-7t-(2-phenoxy-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carbothioic acid S-(3-nitro-pyridin-2-yl) ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (6R)-3-methyl-8-oxo-7t-(2-phenoxy-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carbothioic acid S-(3-nitro-pyridin-2-yl) ester

There total 1 articles about (6R)-3-methyl-8-oxo-7t-(2-phenoxy-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carbothioic acid S-(3-nitro-pyridin-2-yl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-nitro-2-pyridinesulfenyl chloride (68206-45-1) + (6R)-3-methyl-7t-(2-phenoxy-acetylamino)-8-oxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid; sodium salt (39647-22-8) → (6R)-3-methyl-8-oxo-7t-(2-phenoxy-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carbothioic acid S-(3-nitro-pyridin-2-yl) ester (68206-41-7)

Guidance literature:

With triphenylphosphine; In dichloromethane;

DOI:10.1246/cl.1978.979

Reference yield:

(6R)-3-methyl-8-oxo-7t-(2-phenoxy-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carbothioic acid S-(3-nitro-pyridin-2-yl) ester (68206-41-7) + glycerol (56-81-5,25618-55-7,64333-26-2,8013-25-0) → (6R)-3-methyl-8-oxo-7t-(2-phenoxy-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid (Ξ)-2,3-dihydroxy-propyl ester (68206-42-8)

Guidance literature:

With mercury(II) diacetate; Ambient temperature;

DOI:10.1246/cl.1978.979

upstream raw materials:

3-nitro-2-pyridinesulfenyl chloride

(6R)-3-methyl-7t-(2-phenoxy-acetylamino)-8-oxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid; sodium salt

Downstream raw materials:

(6R)-3-methyl-8-oxo-7t-(2-phenoxy-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid (Ξ)-2,3-dihydroxy-propyl ester