3-NITRO-2-PYRIDINESULFENYL CHLORIDE

Base Information

• Chemical Name: 3-NITRO-2-PYRIDINESULFENYL CHLORIDE
• CAS No.: 68206-45-1
• Molecular Formula: C5H3ClN2O2S
• Molecular Weight: 190.61
• Mol file: 68206-45-1.mol

Synonyms:2-Pyridinesulfenyl chloride, 3-nitro-;(3-Nitro-2-pyridyl)sulfenyl chloride;3-Nitro-2-pyridinesulfenyl chloride;Pyridine, 2-chlorothio-3-nitro-;Hypochlorothioous acid,3-nitro-2-pyridinyl ester;

Chemical Property of 3-NITRO-2-PYRIDINESULFENYL CHLORIDE

Chemical Property:

• Vapor Pressure: 0.005mmHg at 25°C
• Melting Point: 205 ºC
• Boiling Point: 376.8 °C at 760 mmHg
• PKA: -3.72±0.29(Predicted)
• Flash Point: 181.7 °C
• PSA: 84.01000
• Density: 1.58 g/cm³
• LogP: 2.75890
• Storage Temp.: 2-8°C
• Solubility.: dichloromethane: soluble(lit.)

Purity/Quality:

90.0%Min ^*data from raw suppliers

[(3-nitropyridin-2-yl)sulfanyl]chlorane ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-27-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3-Nitro-2-pyridinesulfenyl chloride (NpysCl) was employed as the starting material for the synthesis of N-, O- and S-Npys-protected amino acid.

Technology Process of 3-NITRO-2-PYRIDINESULFENYL CHLORIDE

There total 4 articles about 3-NITRO-2-PYRIDINESULFENYL CHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

benzyl 3-nitro-2-pyridyl sulfide (69212-31-3) → 3-nitro-2-pyridinesulfenyl chloride (68206-45-1)

Guidance literature:

With pyridine; sulfuryl dichloride; In 1,2-dichloro-ethane; for 1h;

DOI:10.1055/s-1994-25394

Reference yield:

2-Chloro-3-nitropyridine (5470-18-8,34515-82-7) → 3-nitro-2-pyridinesulfenyl chloride (68206-45-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 93 percent / TEA / methanol / 4 h / Heating

2: SO₂Cl₂ / CH₂Cl₂ / 0.33 h

With sulfuryl dichloride; TEA; In methanol; dichloromethane;

DOI:10.1055/s-1994-25394

Reference yield:

4-methoxybenzyl 3-nitro-2-pyridyl sulfide (153815-22-6) → 3-nitro-2-pyridinesulfenyl chloride (68206-45-1)

Guidance literature:

With sulfuryl dichloride; In dichloromethane; for 0.333333h;

DOI:10.1055/s-1994-25394

upstream raw materials:

benzyl 3-nitro-2-pyridyl sulfide

4-methoxybenzyl 3-nitro-2-pyridyl sulfide

2-Chloro-3-nitropyridine

Downstream raw materials:

C₅₅H₈₄N₁₆O₂₄S₂

C₆₆H₁₀₃N₁₅O₂₇S₂

(6R)-7t-((R)-2-tert-butoxycarbonylamino-2-phenyl-acetylamino)-3-methyl-8-oxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carbothioic acid S-(3-nitro-pyridin-2-yl) ester

(6R)-3-methyl-8-oxo-7t-(2-phenoxy-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carbothioic acid S-(3-nitro-pyridin-2-yl) ester