Technology Process of 2-(1-acetoxy-4,5-dimethoxy-naphthalen-2-yl)-3-methoxy-benzoic acid methyl ester
There total 22 articles about 2-(1-acetoxy-4,5-dimethoxy-naphthalen-2-yl)-3-methoxy-benzoic acid methyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 13 steps
1: 97 percent / (i-Pr)2NEt / CH2Cl2 / -78 °C
2: 85 percent / (Ph3P)2PdCl2 / dimethylformamide / 90 °C
3: 100 percent / K2CO3 / methanol
4: 95 percent / Et4N(1+)(HBr2)(1-) / CH2Cl2
5: 98 percent / LiAlH4 / tetrahydrofuran / -78 - 0 °C
6: 94 percent / MnO2 / CHCl3 / Heating
7: 89 percent / TsOH / toluene / Heating
8: 90 percent / t-BuLi / diethyl ether / -78 °C
9: 96 percent / toluene / 7.5 h / 110 °C
10: 97 percent / 4-DMAP; pyridine
11: 97 percent / aq. AcOH
12: NaClO2; NaH2PO4; 2-methyl-2-butene / H2O; acetone
13: methanol; benzene
With
pyridine; dmap; manganese(IV) oxide; sodium chlorite; sodium dihydrogenphosphate; lithium aluminium tetrahydride; 2-methyl-but-2-ene; Et4N(1+)*(HBr2)(1-); tert.-butyl lithium; potassium carbonate; toluene-4-sulfonic acid; acetic acid; N-ethyl-N,N-diisopropylamine;
bis-triphenylphosphine-palladium(II) chloride;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; chloroform; water; N,N-dimethyl-formamide; acetone; toluene; benzene;
2: Sonogashira reaction;
DOI:10.1016/j.tetlet.2006.06.078
- Guidance literature:
-
Multi-step reaction with 12 steps
1: 85 percent / (Ph3P)2PdCl2 / dimethylformamide / 90 °C
2: 100 percent / K2CO3 / methanol
3: 95 percent / Et4N(1+)(HBr2)(1-) / CH2Cl2
4: 98 percent / LiAlH4 / tetrahydrofuran / -78 - 0 °C
5: 94 percent / MnO2 / CHCl3 / Heating
6: 89 percent / TsOH / toluene / Heating
7: 90 percent / t-BuLi / diethyl ether / -78 °C
8: 96 percent / toluene / 7.5 h / 110 °C
9: 97 percent / 4-DMAP; pyridine
10: 97 percent / aq. AcOH
11: NaClO2; NaH2PO4; 2-methyl-2-butene / H2O; acetone
12: methanol; benzene
With
pyridine; dmap; manganese(IV) oxide; sodium chlorite; sodium dihydrogenphosphate; lithium aluminium tetrahydride; 2-methyl-but-2-ene; Et4N(1+)*(HBr2)(1-); tert.-butyl lithium; potassium carbonate; toluene-4-sulfonic acid; acetic acid;
bis-triphenylphosphine-palladium(II) chloride;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; chloroform; water; N,N-dimethyl-formamide; acetone; toluene; benzene;
1: Sonogashira reaction;
DOI:10.1016/j.tetlet.2006.06.078
- Guidance literature:
-
Multi-step reaction with 11 steps
1: 100 percent / K2CO3 / methanol
2: 95 percent / Et4N(1+)(HBr2)(1-) / CH2Cl2
3: 98 percent / LiAlH4 / tetrahydrofuran / -78 - 0 °C
4: 94 percent / MnO2 / CHCl3 / Heating
5: 89 percent / TsOH / toluene / Heating
6: 90 percent / t-BuLi / diethyl ether / -78 °C
7: 96 percent / toluene / 7.5 h / 110 °C
8: 97 percent / 4-DMAP; pyridine
9: 97 percent / aq. AcOH
10: NaClO2; NaH2PO4; 2-methyl-2-butene / H2O; acetone
11: methanol; benzene
With
pyridine; dmap; manganese(IV) oxide; sodium chlorite; sodium dihydrogenphosphate; lithium aluminium tetrahydride; 2-methyl-but-2-ene; Et4N(1+)*(HBr2)(1-); tert.-butyl lithium; potassium carbonate; toluene-4-sulfonic acid; acetic acid;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; chloroform; water; acetone; toluene; benzene;
DOI:10.1016/j.tetlet.2006.06.078
