(9R)-12,13-de-epoxy-12,13-dehydro-20-deoxo-9-dehydro-rosaramicin 20-diphenylthioacetal

Base Information

Chemical Name:(9R)-12,13-de-epoxy-12,13-dehydro-20-deoxo-9-dehydro-rosaramicin 20-diphenylthioacetal
CAS No.:112389-35-2
Molecular Formula:C₄₃H₆₃NO₇S₂
Molecular Weight:770.108
Hs Code.:

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (9R)-12,13-de-epoxy-12,13-dehydro-20-deoxo-9-dehydro-rosaramicin 20-diphenylthioacetal

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Technology Process of (9R)-12,13-de-epoxy-12,13-dehydro-20-deoxo-9-dehydro-rosaramicin 20-diphenylthioacetal

There total 6 articles about (9R)-12,13-de-epoxy-12,13-dehydro-20-deoxo-9-dehydro-rosaramicin 20-diphenylthioacetal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 112389-34-1
(11E,13E)-(4R,5S,6S,7R,9R,15S,16R)-7-(2,2-Bis-phenylsulfanyl-ethyl)-6-((2S,3R,4S,6R)-4-dimethylamino-3-hydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-16-ethyl-4-hydroxy-5,9,13,15-tetramethyl-oxacyclohexadeca-11,13-diene-2,10-dione

: 112389-35-2,112457-02-0
(9S)-12,13-de-epoxy-12,13-dehydro-20-deoxo-9-dehydro-rosaramicin 20-diphenylthioacetal

: 112389-35-2,112457-02-0
(9R)-12,13-de-epoxy-12,13-dehydro-20-deoxo-9-dehydro-rosaramicin 20-diphenylthioacetal

Guidance literature:: With sodium tetrahydroborate; In methanol; at 25 ℃; for 3.5h;

Reference yield: 56.0%

: 112389-34-1
(11E,13E)-(4R,5S,6S,7R,9R,15S,16R)-7-(2,2-Bis-phenylsulfanyl-ethyl)-6-((2S,3R,4S,6R)-4-dimethylamino-3-hydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-16-ethyl-4-hydroxy-5,9,13,15-tetramethyl-oxacyclohexadeca-11,13-diene-2,10-dione

: 112389-35-2,112457-02-0
(9S)-12,13-de-epoxy-12,13-dehydro-20-deoxo-9-dehydro-rosaramicin 20-diphenylthioacetal

: 112389-35-2,112457-02-0
(9R)-12,13-de-epoxy-12,13-dehydro-20-deoxo-9-dehydro-rosaramicin 20-diphenylthioacetal

Guidance literature:: With sodium tetrahydroborate; In methanol; at 25 ℃; for 3.5h;

Reference yield:

: 2',20-di-O-acetyl-12,13-de-epoxy-12,13-dehydrorosaramicin 3,20-hemiacetal

: 112389-35-2,112457-02-0
(9S)-12,13-de-epoxy-12,13-dehydro-20-deoxo-9-dehydro-rosaramicin 20-diphenylthioacetal

Guidance literature:: Multi-step reaction with 3 steps

1: 1 percent / 1.) borohydride exchange resin; 2.) triethyl amine / 1.) methanol, 25 deg C, 24 h; 2.) methanol, 65 deg C, 48 h

2: 44 percent / tributylphosphine / tetrahydrofuran / 24 h / 25 °C

3: 6 percent / sodium borohydride / methanol / 3.5 h / 25 °C

With sodium tetrahydroborate; borohydride exchange resin; tributylphosphine; triethylamine; In tetrahydrofuran; methanol;