10beta,17beta-Dihydroxyestra-1,4-dien-3-one

Base Information

Chemical Name:10beta,17beta-Dihydroxyestra-1,4-dien-3-one
CAS No.:549-02-0
Molecular Formula:C₁₈H₂₄O₃
Molecular Weight:288.387
Hs Code.:
UNII:UR9WW8CA3J
DSSTox Substance ID:DTXSID501337122
Nikkaji Number:J1.289.566F

Synonyms:3,16-dihydroxyandrost-5-ene-17,19-dione;DHED

Suppliers and Price of 10beta,17beta-Dihydroxyestra-1,4-dien-3-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 8 raw suppliers

Chemical Property of 10beta,17beta-Dihydroxyestra-1,4-dien-3-one

Chemical Property:

XLogP3:1.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:0
Exact Mass:288.17254462
Heavy Atom Count:21
Complexity:549

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC12CCC3C(C1CCC2O)CCC4=CC(=O)C=CC34O
Isomeric SMILES:C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2O)CCC4=CC(=O)C=C[C@]34O
Uses DHED has been used to induce an increase of estrogen levels in 3K transgenic mice with Parkinson′s disease (PD)-like motor syndrome.

Technology Process of 10beta,17beta-Dihydroxyestra-1,4-dien-3-one

There total 9 articles about 10beta,17beta-Dihydroxyestra-1,4-dien-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 50-28-2
estradiol

: 549-02-0
10β,17β-dihydroxyestra-1,4-dien-3-one

Guidance literature:: With hydrogenchloride; potassium permanganate; In ethyl acetate;
DOI:10.1016/j.steroids.2006.04.002

Reference yield: 75.0%

: 10β-hydroperoxy-17β-hydroxy-estra-1(2),4(5)-dien-3-one

: 549-02-0
10β,17β-dihydroxyestra-1,4-dien-3-one

Guidance literature:: With sodium thiosulfate; In methanol; water; at 20 ℃;
DOI:10.1002/chem.202101313

Reference yield: 33.0%

: 108681-22-7
2,4-dibromo-10β,17β-dihydroxy-1,4-estradien-3-one

: 549-02-0
10β,17β-dihydroxyestra-1,4-dien-3-one

: 126093-39-8
4-bromo-10β,17β-dihydroxy-1,4-estradien-3-one

Guidance literature:: With formic acid; triethylamine; palladium on activated charcoal; In methanol; for 10h; Heating;
DOI:10.1248/cpb.37.2058