(S_P)-N⁶-benzoyl-3'-O-(t.butyldimethylsilyl)-5'-O-(dimethoxytrityl)-P-thioadenylyl-(2'-5')-N⁶-benzoyl-2',3'-O-(1,1,3,3-tetraisopropyl-1,3-disiloxanediyl)adenosine, triethylammonium salt

Base Information

• Chemical Name: (S_P)-N⁶-benzoyl-3'-O-(t.butyldimethylsilyl)-5'-O-(dimethoxytrityl)-P-thioadenylyl-(2'-5')-N⁶-benzoyl-2',3'-O-(1,1,3,3-tetraisopropyl-1,3-disiloxanediyl)adenosine, triethylammonium salt
• CAS No.: 142025-20-5
• Molecular Formula: C₆H₁₅N*C₇₃H₉₁N₁₀O₁₄PSSi₃
• Molecular Weight: 1581.07

Synonyms:

Chemical Property of (S_P)-N⁶-benzoyl-3'-O-(t.butyldimethylsilyl)-5'-O-(dimethoxytrityl)-P-thioadenylyl-(2'-5')-N⁶-benzoyl-2',3'-O-(1,1,3,3-tetraisopropyl-1,3-disiloxanediyl)adenosine, triethylammonium salt

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of (S_P)-N⁶-benzoyl-3'-O-(t.butyldimethylsilyl)-5'-O-(dimethoxytrityl)-P-thioadenylyl-(2'-5')-N⁶-benzoyl-2',3'-O-(1,1,3,3-tetraisopropyl-1,3-disiloxanediyl)adenosine, triethylammonium salt

There total 1 articles about (S_P)-N⁶-benzoyl-3'-O-(t.butyldimethylsilyl)-5'-O-(dimethoxytrityl)-P-thioadenylyl-(2'-5')-N⁶-benzoyl-2',3'-O-(1,1,3,3-tetraisopropyl-1,3-disiloxanediyl)adenosine, triethylammonium salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N6-benzoyl-2',3'-O-(1,1,3,3-tetraisopropyl-1,3-disiloxanediyl)adenosine (135732-99-9) + (2R,3R,4R,5R)-2-(6-benzamido-9H-purin-9-yl)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)tetrahydrofuran-3-yl phosphonate triethylamine salt (142025-14-7) + triethylamine (121-44-8) → (SP)-N6-benzoyl-3'-O-(t.butyldimethylsilyl)-5'-O-(dimethoxytrityl)-P-thioadenylyl-(2'-5')-N6-benzoyl-2',3'-O-(1,1,3,3-tetraisopropyl-1,3-disiloxanediyl)adenosine, triethylammonium salt (142025-20-5,142129-31-5) + (RP)-N6-benzoyl-3'-O-(t.butyldimethylsilyl)-5'-O-(dimethoxytrityl)-P-thioadenylyl-(2'-5')-N6-benzoyl-2',3'-O-(1,1,3,3-tetraisopropyl-1,3-disiloxanediyl)adenosine, triethylammonium salt

Guidance literature:

With pyridine; pivaloyl chloride; sulfur; Yield given. Multistep reaction. Yields of byproduct given; 1) RT, 30 min, 2) RT, 2.5 h;

DOI:10.1016/S0040-4020(01)92259-8

Reference yield: 95.0%

(SP)-N6-benzoyl-3'-O-(t.butyldimethylsilyl)-5'-O-(dimethoxytrityl)-P-thioadenylyl-(2'-5')-N6-benzoyl-2',3'-O-(1,1,3,3-tetraisopropyl-1,3-disiloxanediyl)adenosine, triethylammonium salt (142025-20-5,142129-31-5) → N6-benzoyl-3'-O-(t.butyldimethylsilyl)-(SP)-P-thioadenylyl-(2'-5')-N6-benzoyl-2',3'-O-(1,1,3,3-tetraisopropyl-1,3-disiloxanediyl)adenosine, triethylammonium salt (142025-24-9)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 0 ℃; for 0.5h;

DOI:10.1016/S0040-4020(01)92259-8

upstream raw materials:

N⁶-benzoyl-2',3'-O-(1,1,3,3-tetraisopropyl-1,3-disiloxanediyl)adenosine

(2R,3R,4R,5R)-2-(6-benzamido-9H-purin-9-yl)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)tetrahydrofuran-3-yl phosphonate triethylamine salt

triethylamine

Downstream raw materials:

N⁶-benzoyl-3'-O-(t.butyldimethylsilyl)-(S_P)-P-thioadenylyl-(2'-5')-N⁶-benzoyl-2',3'-O-(1,1,3,3-tetraisopropyl-1,3-disiloxanediyl)adenosine, triethylammonium salt

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