Adenosine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-3'-O-[(1,1-dimethyl ethyl)dimethylsilyl]-, 2'-(hydrogen phosphonate), compd. with N,N-diethylethanamine (1:1)

Base Information

Chemical Name:Adenosine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-3'-O-[(1,1-dimethyl ethyl)dimethylsilyl]-, 2'-(hydrogen phosphonate), compd. with N,N-diethylethanamine (1:1)
CAS No.:142025-14-7
Molecular Formula:C44H50N5O9PSi.C6H15N
Molecular Weight:953.16
Hs Code.:

Adenosine,
N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-3'-O-[(1,1-dimethyl
ethyl)dimethylsilyl]-, 2'-(hydrogen phosphonate), compd. with
N,N-diethylethanamine (1:1)

Synonyms:

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Chemical Property of Adenosine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-3'-O-[(1,1-dimethyl ethyl)dimethylsilyl]-, 2'-(hydrogen phosphonate), compd. with N,N-diethylethanamine (1:1)

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Technology Process of Adenosine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-3'-O-[(1,1-dimethyl ethyl)dimethylsilyl]-, 2'-(hydrogen phosphonate), compd. with N,N-diethylethanamine (1:1)

There total 1 articles about Adenosine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-3'-O-[(1,1-dimethyl ethyl)dimethylsilyl]-, 2'-(hydrogen phosphonate), compd. with N,N-diethylethanamine (1:1) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 15715-58-9
triethylamine carbonate

: 81256-88-4
N-(9-((2R,3R,4S,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-3-hydroxytetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide

: 142025-14-7
(2R,3R,4R,5R)-2-(6-benzamido-9H-purin-9-yl)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)tetrahydrofuran-3-yl phosphonate triethylamine salt

Guidance literature:: With 4-methyl-morpholine; 1,2,4-Triazole; phosphorus trichloride; 1) CH₂Cl₂, 0 deg C, 10 min, 2) H₂O, pH 8.5;
DOI:10.1016/S0040-4020(01)92259-8

Reference yield:

: 142025-14-7
(2R,3R,4R,5R)-2-(6-benzamido-9H-purin-9-yl)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)tetrahydrofuran-3-yl phosphonate triethylamine salt

: (2R,3R,4R,5R)-2-(6-benzamido-9H-purin-9-yl)-4-((tert-butyldimethylsilyl)oxy)-5-(hydroxymethyl)tetrahydrofuran-3-yl hydrogen phosphonate

Guidance literature:: (2R,3R,4R,5R)-2-(6-benzamido-9H-purin-9-yl)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)tetrahydrofuran-3-yl phosphonate triethylamine salt; With dichloro-acetic acid; water; In dichloromethane; at 25 ℃; for 0.5h;

With pyridine; triethylsilane; In dichloromethane; for 1.5h;

Reference yield:

: 142025-14-7
(2R,3R,4R,5R)-2-(6-benzamido-9H-purin-9-yl)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)tetrahydrofuran-3-yl phosphonate triethylamine salt

: 142025-30-7,142129-33-7
3'-O-(t.butyldimethylsilyl)-(S_P)-P-thioadenylyl-(2'-5')-2',3'-O-bis(t.butyldimethylsilyl)adenosine, triethylammonium salt

: (S_P)-N⁶-benzoyl-3'-O-(t.butyldimethylsilyl)-5'-O-(dimethoxytrityl)-P-thioadenylyl-(2'-5')-3'-O-(t.butyldimethylsilyl)-(S_P)-P-thioadenylyl-(2'-5')-2',3'-O-bis(t.butyldimethylsilyl)adenosine, triethylammonium salt

: (R_P)-N⁶-benzoyl-3'-O-(t.butyldimethylsilyl)-5'-O-(dimethoxytrityl)-P-thioadenylyl-(2'-5')-3'-O-(t.butyldimethylsilyl)-(S_P)-P-thioadenylyl-(2'-5')-2',3'-O-bis(t.butyldimethylsilyl)adenosine, triethylammonium salt

Guidance literature:: With pyridine; sulfur; 1-adamantanecarboxylic acid chloride; Yield given. Multistep reaction. Yields of byproduct given; 1) RT, 1 h, 2) RT, 3 h;
DOI:10.1016/S0040-4020(01)92259-8