(-Tyr-Arg-Lys-Asp-L-Val-)*2HOAc

Base Information

• Chemical Name: (-Tyr-Arg-Lys-Asp-L-Val-)*2HOAc
• CAS No.: 100164-91-8
• Molecular Formula: 2C₂H₄O₂*C₃₀H₄₇N₉O₈
• Molecular Weight: 781.864
• Mol file: 100164-91-8.mol

Synonyms:

Chemical Property of (-Tyr-Arg-Lys-Asp-L-Val-)*2HOAc

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (-Tyr-Arg-Lys-Asp-L-Val-)*2HOAc

There total 35 articles about (-Tyr-Arg-Lys-Asp-L-Val-)*2HOAc which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl L-valinate (13211-31-9) → (-Tyr-Arg-Lys-Asp-L-Val-)*2HOAc (96356-59-1,96393-64-5,100164-85-0,100164-91-8)

Guidance literature:

Multi-step reaction with 6 steps

1: PPA

3: PPA

5: 30 percent / EDCI / DMAP / CH₂Cl₂; dimethylformamide

6: H₂ / Pd-charcoal / methanol

With hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4039(00)61873-7

Reference yield:

Boc-Arg(NO2)-OH (2188-18-3) → (-Tyr-Arg-Lys-Asp-L-Val-)*2HOAc (96356-59-1,96393-64-5,100164-85-0,100164-91-8)

Guidance literature:

Multi-step reaction with 8 steps

1: PPA

2: trifluoroacetic acid

3: PPA

5: PPA

7: 30 percent / EDCI / DMAP / CH₂Cl₂; dimethylformamide

8: H₂ / Pd-charcoal / methanol

With hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; dmap; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4039(00)61873-7

Reference yield:

H-Tyr-Arg-NO2-Lys-Z-Asp-OBzl-L-Val-Y*TFA (97251-06-4) → (-Tyr-Arg-Lys-Asp-L-Val-)*2HOAc (96356-59-1,96393-64-5,100164-85-0,100164-91-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 30 percent / EDCI / DMAP / CH₂Cl₂; dimethylformamide

2: H₂ / Pd-charcoal / methanol

With hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4039(00)61873-7

upstream raw materials:

acetic acid

cyclo<-Tyr-Arg(NO2)-D-Lys(Z)-Asp(OBzl)-D-Val->

benzyl (S)-1-(tert-butoxycarbonyl)-2-methylpropylcarbamate

Boc-Tyr dicyclohexylammonium salt

Refernces

• 1、 Kessler, Horst,Kutscher, Bernhard. "SYNTHESIS AND NMR INVESTIGATION OF CYCLIC PENTAPEPTIDE ANALOGUES OF THYMOPENTIN". . p. 177 - 180. Retrieved 2007/10/02.