Technology Process of (2-RS)-2-cyano-3,3-diphenylpropanoyl chloride
There total 1 articles about (2-RS)-2-cyano-3,3-diphenylpropanoyl chloride which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
oxalyl dichloride; N,N-dimethyl-formamide;
In
dichloromethane;
for 2.5h;
Ambient temperature;
DOI:10.1002/jhet.5570320125
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1.) AgCN; 2.) CH3MgBr / 1.) PhMe, 80 deg C, 4 h; 2.) THF, 0 deg C, 1 h
2: 71 percent / Li diisopropylamide / tetrahydrofuran; hexamethylphosphoric acid triamide / 12 h / Ambient temperature
3: 89 percent / 10percent KOH-MeOH / 5 h / Heating
4: PCl5 / diethyl ether / 1 h / Ambient temperature
With
potassium hydroxide; silver cyanide; phosphorus pentachloride; methylmagnesium bromide; lithium diisopropyl amide;
In
tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; diethyl ether;
DOI:10.1016/S0040-4020(01)85549-6
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1.) AgCN; 2.) CH3MgBr / 1.) PhMe, 80 deg C, 4 h; 2.) THF, 0 deg C, 1 h
2: 71 percent / Li diisopropylamide / tetrahydrofuran; hexamethylphosphoric acid triamide / 12 h / Ambient temperature
3: 89 percent / 10percent KOH-MeOH / 5 h / Heating
With
potassium hydroxide; silver cyanide; methylmagnesium bromide; lithium diisopropyl amide;
In
tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide;
DOI:10.1016/S0040-4020(01)85549-6
