(2R)-(1S,2R,4R)-10-dicyclohexylsulfamoylisobornyl 2-cyano-3,3-diphenyl-2-methylpropanoate

Base Information

Chemical Name:(2R)-(1S,2R,4R)-10-dicyclohexylsulfamoylisobornyl 2-cyano-3,3-diphenyl-2-methylpropanoate
CAS No.:160560-25-8
Molecular Formula:C₃₉H₅₂N₂O₄S
Molecular Weight:644.919
Hs Code.:

Synonyms:(2R)-(1S,2R,4R)-10-dicyclohexylsulfamoylisobornyl 2-cyano-3,3-diphenyl-2-methylpropanoate

Suppliers and Price of (2R)-(1S,2R,4R)-10-dicyclohexylsulfamoylisobornyl 2-cyano-3,3-diphenyl-2-methylpropanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2R)-(1S,2R,4R)-10-dicyclohexylsulfamoylisobornyl 2-cyano-3,3-diphenyl-2-methylpropanoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2R)-(1S,2R,4R)-10-dicyclohexylsulfamoylisobornyl 2-cyano-3,3-diphenyl-2-methylpropanoate

There total 3 articles about (2R)-(1S,2R,4R)-10-dicyclohexylsulfamoylisobornyl 2-cyano-3,3-diphenyl-2-methylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: (1S,2R,4R)-10-dicyclohexylsulfamoylisobornyl 2-cyano-3,3-diphenylpropanoate

: 74-88-4
methyl iodide

: (2S)-(1S,2R,4R)-10-dicyclohexylsulfamoylisobornyl 2-cyano-3,3-diphenyl-2-methylpropanoate

: 160560-25-8
(2R)-(1S,2R,4R)-10-dicyclohexylsulfamoylisobornyl 2-cyano-3,3-diphenyl-2-methylpropanoate

Guidance literature:: With lithium diisopropyl amide; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; for 12h; Yield given; Ambient temperature;
DOI:10.1016/S0040-4020(01)85549-6

Reference yield:

: 96303-88-7
(-)-10-dicyclohexylsulfamoyl-D-isoborneol

: 160560-25-8
(2R)-(1S,2R,4R)-10-dicyclohexylsulfamoylisobornyl 2-cyano-3,3-diphenyl-2-methylpropanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) AgCN; 2.) CH₃MgBr / 1.) PhMe, 80 deg C, 4 h; 2.) THF, 0 deg C, 1 h

2: 71 percent / Li diisopropylamide / tetrahydrofuran; hexamethylphosphoric acid triamide / 12 h / Ambient temperature

With silver cyanide; methylmagnesium bromide; lithium diisopropyl amide; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide;
DOI:10.1016/S0040-4020(01)85549-6

Reference yield:

: 160560-23-6
(2-RS)-2-cyano-3,3-diphenylpropanoyl chloride

: 160560-25-8
(2R)-(1S,2R,4R)-10-dicyclohexylsulfamoylisobornyl 2-cyano-3,3-diphenyl-2-methylpropanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) AgCN; 2.) CH₃MgBr / 1.) PhMe, 80 deg C, 4 h; 2.) THF, 0 deg C, 1 h

2: 71 percent / Li diisopropylamide / tetrahydrofuran; hexamethylphosphoric acid triamide / 12 h / Ambient temperature

With silver cyanide; methylmagnesium bromide; lithium diisopropyl amide; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide;
DOI:10.1016/S0040-4020(01)85549-6