(R)-3-(4,4-dimethylpyrrolidin-2-yl)pyridine (+)-phencyphos salt

Base Information

Chemical Name:(R)-3-(4,4-dimethylpyrrolidin-2-yl)pyridine (+)-phencyphos salt
CAS No.:1426540-40-0
Molecular Formula:C₁₁H₁₅O₄P*C₁₁H₁₆N₂
Molecular Weight:418.473
Hs Code.:

Synonyms:

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Chemical Property of (R)-3-(4,4-dimethylpyrrolidin-2-yl)pyridine (+)-phencyphos salt

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Technology Process of (R)-3-(4,4-dimethylpyrrolidin-2-yl)pyridine (+)-phencyphos salt

There total 6 articles about (R)-3-(4,4-dimethylpyrrolidin-2-yl)pyridine (+)-phencyphos salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1426540-39-7
(R)-3-(4,4-dimethylpyrrolidin-2-yl)pyridine

: 98674-81-8
(S)-(+)-5,5-dimethyl-2-hydroxy-4-phenyl-1,3,2-dioxaphosphorinane 2-oxide

: 1426540-40-0
(R)-3-(4,4-dimethylpyrrolidin-2-yl)pyridine (+)-phencyphos salt

Guidance literature:: In ethyl acetate; isopropyl alcohol; Inert atmosphere; Heating;
DOI:10.1016/j.bmcl.2013.01.067

Reference yield:

: 3437-29-4
3,3-dimethylpyrrolidine-2,5-dione

: 1426540-40-0
(R)-3-(4,4-dimethylpyrrolidin-2-yl)pyridine (+)-phencyphos salt

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 15 h / Inert atmosphere; Reflux

2.1: tetrahydrofuran / 2 h / 10 - 15 °C / Inert atmosphere

3.1: (-)-sparteine; sec.-butyllithium / tert-butyl methyl ether / 4.5 h / -78 - 78 °C / Inert atmosphere

3.2: 1 h / -78 - 20 °C / Inert atmosphere

3.3: 17 h / 25 - 30 °C / Inert atmosphere

4.1: trifluoroacetic acid / 0.5 h / 20 - 25 °C / Inert atmosphere

5.1: isopropyl alcohol; ethyl acetate / Inert atmosphere; Heating

With lithium aluminium tetrahydride; sec.-butyllithium; trifluoroacetic acid; (-)-sparteine; In tetrahydrofuran; tert-butyl methyl ether; ethyl acetate; isopropyl alcohol; 3.3: |Negishi Coupling;
DOI:10.1016/j.bmcl.2013.01.067

Reference yield:

: 851429-33-9
tert-butyl 3,3-dimethylpyrrolidine-1-carboxylate

: 1426540-40-0
(R)-3-(4,4-dimethylpyrrolidin-2-yl)pyridine (+)-phencyphos salt

Guidance literature:: Multi-step reaction with 3 steps

1.1: (-)-sparteine; sec.-butyllithium / tert-butyl methyl ether / 4.5 h / -78 - 78 °C / Inert atmosphere

1.2: 1 h / -78 - 20 °C / Inert atmosphere

1.3: 17 h / 25 - 30 °C / Inert atmosphere

2.1: trifluoroacetic acid / 0.5 h / 20 - 25 °C / Inert atmosphere

3.1: isopropyl alcohol; ethyl acetate / Inert atmosphere; Heating

With sec.-butyllithium; trifluoroacetic acid; (-)-sparteine; In tert-butyl methyl ether; ethyl acetate; isopropyl alcohol; 1.3: |Negishi Coupling;
DOI:10.1016/j.bmcl.2013.01.067