(4S)-2-Hydroxy-5,5-dimethyl-4-phenyl-1,3,2-dioxaphosphinane 2-oxide

Base Information

Chemical Name:(4S)-2-Hydroxy-5,5-dimethyl-4-phenyl-1,3,2-dioxaphosphinane 2-oxide
CAS No.:98674-81-8
Molecular Formula:C11H15 O4 P
Molecular Weight:242.211
Hs Code.:2934999090
DSSTox Substance ID:DTXSID101145389
Nikkaji Number:J1.307.356B,J2.313.287G
Mol file:98674-81-8.mol

Synonyms:98674-81-8;(4S)-2-Hydroxy-5,5-dimethyl-4-phenyl-1,3,2-dioxaphosphinane 2-oxide;(4S)-2-Hydroxy-5,5-dimethyl-4-phenyl-1,3,2lambda5-dioxaphosphinane 2-oxide;SCHEMBL2360352;DTXSID101145389;(4S)-2-Hydroxy-4-phenyl-5,5-dimethyl-1,3,2-dioxaphosphorinane 2-oxide;(4S)-2-Hydroxy-5,5-dimethyl-4-phenyl-1,3,2-dioxaphosphinane2-oxide;1,3,2-Dioxaphosphorinane, 2-hydroxy-5,5-dimethyl-4-phenyl-, 2-oxide, (4S)-

Suppliers and Price of (4S)-2-Hydroxy-5,5-dimethyl-4-phenyl-1,3,2-dioxaphosphinane 2-oxide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Atlantic Research Chemicals
(S)-4-Phenyl-5,5-dimethyl-2-hydroxy-1,3,2-dioxaphosphorinane-2-oxide 95%
1gm:
$ 166.12

American Custom Chemicals Corporation
(S)-(+)-5,5-DIMETHYL-2-HYDROXY 4-PHENYL-1,3,2-DIOXAPHOS-PHORINANE-2-OXIDE 95.00%
5MG
$ 498.93

Total 9 raw suppliers

Chemical Property of (4S)-2-Hydroxy-5,5-dimethyl-4-phenyl-1,3,2-dioxaphosphinane 2-oxide

Chemical Property:

Vapor Pressure:2.51E-05mmHg at 25°C
Melting Point:223-227 °C(lit.)
Boiling Point:344.4°Cat760mmHg
Flash Point:162.1°C
PSA：65.57000
Density:1.27g/cm³
LogP:2.90110
XLogP3:1.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:242.07079595
Heavy Atom Count:16
Complexity:296

Purity/Quality:

98%Min ^*data from raw suppliers

(S)-4-Phenyl-5,5-dimethyl-2-hydroxy-1,3,2-dioxaphosphorinane-2-oxide 95% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:Xi
Statements: 36/37/38
Safety Statements: 26-36

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1(COP(=O)(OC1C2=CC=CC=C2)O)C
Isomeric SMILES:CC1(COP(=O)(O[C@H]1C2=CC=CC=C2)O)C

Technology Process of (4S)-2-Hydroxy-5,5-dimethyl-4-phenyl-1,3,2-dioxaphosphinane 2-oxide

There total 8 articles about (4S)-2-Hydroxy-5,5-dimethyl-4-phenyl-1,3,2-dioxaphosphinane 2-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (S)-(+)-2-chloro-4-(phenyl)-5,5-dimethyl-1,3,2-dioxaphosphinan-2-one

: 98674-81-8
(S)-(+)-5,5-dimethyl-2-hydroxy-4-phenyl-1,3,2-dioxaphosphorinane 2-oxide

Guidance literature:: With sodium hydroxide; at 90 ℃; for 1h;

Reference yield:

: 33950-46-8,98674-79-4
1-phenyl-2,2-dimethyl-1,3-propanediol

: 98674-81-8
(S)-(+)-5,5-dimethyl-2-hydroxy-4-phenyl-1,3,2-dioxaphosphorinane 2-oxide

Guidance literature:: Multi-step reaction with 3 steps

1: POCl₃, triethylamine / CH₂Cl₂ / 3 h / Heating

2: aq. NaOH / 0.25 h / 90 - 95 °C

With sodium hydroxide; triethylamine; trichlorophosphate; In dichloromethane;
DOI:10.1021/jo00223a018

Reference yield:

: 100-52-7
benzaldehyde

: 98674-81-8
(S)-(+)-5,5-dimethyl-2-hydroxy-4-phenyl-1,3,2-dioxaphosphorinane 2-oxide

Guidance literature:: Multi-step reaction with 4 steps

1: 76 percent / KOH / ethanol / 5 h / 50 - 60 °C

2: POCl₃, triethylamine / CH₂Cl₂ / 3 h / Heating

3: aq. NaOH / 0.25 h / 90 - 95 °C

With potassium hydroxide; sodium hydroxide; triethylamine; trichlorophosphate; In ethanol; dichloromethane;
DOI:10.1021/jo00223a018