Technology Process of 2-[1-(2,4-Dimethoxy-phenyl)-meth-(E)-ylidene]-succinic acid diethyl ester
There total 1 articles about 2-[1-(2,4-Dimethoxy-phenyl)-meth-(E)-ylidene]-succinic acid diethyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
potassium tert-butylate;
In
tert-butyl alcohol;
for 2h;
Heating;
DOI:10.1039/b407208a
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: 8.10 g / sodium acetate / 2 h / 140 °C
2.1: 95 percent / guanidine hydrochloride; t-BuOK / ethanol; CH2Cl2 / 1.5 h / 20 °C
3.1: 99 percent / K2CO3 / acetone / 16 h / Heating
4.1: 75 percent / dimethylformamide / 12 h / 170 °C
5.1: 100 percent / K2CO3; KI / acetone / 18 h / Heating
6.1: 95 percent / LiAlH4 / tetrahydrofuran / 18 h / 20 °C
7.1: 78 percent / pyridinium chlorochromate; alumina / acetonitrile; CH2Cl2 / 8 h / 20 °C
8.1: magnesium / diethyl ether
8.2: 95 percent / diethyl ether; tetrahydrofuran / 8 h / 0 - 20 °C
9.1: 92 percent / oxygen; aq. CuCl2; PdCl2 / dimethylformamide / 3 h / 20 °C
With
aluminum oxide; lithium aluminium tetrahydride; potassium tert-butylate; oxygen; guanidine hydrochloride; sodium acetate; potassium carbonate; magnesium; pyridinium chlorochromate; potassium iodide; copper dichloride; palladium dichloride;
In
tetrahydrofuran; diethyl ether; ethanol; dichloromethane; N,N-dimethyl-formamide; acetone; acetonitrile;
4.1: Claisen rearrangement / 8.2: Grignard addition / 9.1: Wacker oxidation;
DOI:10.1039/b407208a
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 8.10 g / sodium acetate / 2 h / 140 °C
2: 95 percent / guanidine hydrochloride; t-BuOK / ethanol; CH2Cl2 / 1.5 h / 20 °C
3: 99 percent / K2CO3 / acetone / 16 h / Heating
4: 75 percent / dimethylformamide / 12 h / 170 °C
5: 100 percent / K2CO3; KI / acetone / 18 h / Heating
6: 95 percent / LiAlH4 / tetrahydrofuran / 18 h / 20 °C
7: 78 percent / pyridinium chlorochromate; alumina / acetonitrile; CH2Cl2 / 8 h / 20 °C
With
aluminum oxide; lithium aluminium tetrahydride; potassium tert-butylate; guanidine hydrochloride; sodium acetate; potassium carbonate; pyridinium chlorochromate; potassium iodide;
In
tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; acetone; acetonitrile;
4: Claisen rearrangement;
DOI:10.1039/b407208a
