methyl 6-(4-hydroxy-2,6-dimethoxy-3-methylphenoxy)-2,4-dimethoxy-3-methylbenzoate

Base Information

• Chemical Name: methyl 6-(4-hydroxy-2,6-dimethoxy-3-methylphenoxy)-2,4-dimethoxy-3-methylbenzoate
• CAS No.: 81574-61-0
• Molecular Formula: C₂₀H₂₄O₈
• Molecular Weight: 392.406
• Mol file: 81574-61-0.mol

Synonyms:

Chemical Property of methyl 6-(4-hydroxy-2,6-dimethoxy-3-methylphenoxy)-2,4-dimethoxy-3-methylbenzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 6-(4-hydroxy-2,6-dimethoxy-3-methylphenoxy)-2,4-dimethoxy-3-methylbenzoate

There total 15 articles about methyl 6-(4-hydroxy-2,6-dimethoxy-3-methylphenoxy)-2,4-dimethoxy-3-methylbenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 2,4-dimethoxy-3-methylbenzoate (6688-71-7) → methyl 6-(4-hydroxy-2,6-dimethoxy-3-methylphenoxy)-2,4-dimethoxy-3-methylbenzoate (81574-61-0)

Guidance literature:

Multi-step reaction with 7 steps

1: 14.6 g / cooper(II) nitrate trihydrate / acetic anhydride / 21 h / Ambient temperature

2: 19.6 g / hydrogen / 10percent palladized charcoal / ethyl acetate / 3040 Torr

3: bromine / CCl₄; CH₂Cl₂ / 0.25 h / -78 °C

4: 16.7 g / concentrated hydrochloric acid, sodium nitrite / H₂O; dioxane / 5 °C

5: 65 percent / potassium carbonate, cooper(II) oxide / pyridine / 15 h / 140 °C

6: 85 percent / hydrogen chloride, titanium(IV) chloride / CH₂Cl₂ / 2 h / Ambient temperature

7: 510 mg / methanol / 1 h / Heating

With hydrogenchloride; hydrogen; bromine; titanium tetrachloride; potassium carbonate; copper(II) nitrate; copper(II) oxide; sodium nitrite; palladium on activated charcoal; In 1,4-dioxane; pyridine; methanol; tetrachloromethane; dichloromethane; water; acetic anhydride; ethyl acetate;

Reference yield:

2,4-dimethoxy-3-methylbenzoic acid (81574-49-4) → methyl 6-(4-hydroxy-2,6-dimethoxy-3-methylphenoxy)-2,4-dimethoxy-3-methylbenzoate (81574-61-0)

Guidance literature:

Multi-step reaction with 8 steps

1: 42.7 g / potassium carbonate / acetone / 1 h / Heating

2: 14.6 g / cooper(II) nitrate trihydrate / acetic anhydride / 21 h / Ambient temperature

3: 19.6 g / hydrogen / 10percent palladized charcoal / ethyl acetate / 3040 Torr

4: bromine / CCl₄; CH₂Cl₂ / 0.25 h / -78 °C

5: 16.7 g / concentrated hydrochloric acid, sodium nitrite / H₂O; dioxane / 5 °C

6: 65 percent / potassium carbonate, cooper(II) oxide / pyridine / 15 h / 140 °C

7: 85 percent / hydrogen chloride, titanium(IV) chloride / CH₂Cl₂ / 2 h / Ambient temperature

8: 510 mg / methanol / 1 h / Heating

With hydrogenchloride; hydrogen; bromine; titanium tetrachloride; potassium carbonate; copper(II) nitrate; copper(II) oxide; sodium nitrite; palladium on activated charcoal; In 1,4-dioxane; pyridine; methanol; tetrachloromethane; dichloromethane; water; acetic anhydride; ethyl acetate; acetone;

Reference yield:

2,4-dimethoxy-3-methylbenzonitrile (81574-51-8) → methyl 6-(4-hydroxy-2,6-dimethoxy-3-methylphenoxy)-2,4-dimethoxy-3-methylbenzoate (81574-61-0)

Guidance literature:

Multi-step reaction with 9 steps

1: 95.7 g / potassium hydroxide / methanol; H₂O / 168 h / Heating

2: 42.7 g / potassium carbonate / acetone / 1 h / Heating

3: 14.6 g / cooper(II) nitrate trihydrate / acetic anhydride / 21 h / Ambient temperature

4: 19.6 g / hydrogen / 10percent palladized charcoal / ethyl acetate / 3040 Torr

5: bromine / CCl₄; CH₂Cl₂ / 0.25 h / -78 °C

6: 16.7 g / concentrated hydrochloric acid, sodium nitrite / H₂O; dioxane / 5 °C

7: 65 percent / potassium carbonate, cooper(II) oxide / pyridine / 15 h / 140 °C

8: 85 percent / hydrogen chloride, titanium(IV) chloride / CH₂Cl₂ / 2 h / Ambient temperature

9: 510 mg / methanol / 1 h / Heating

With hydrogenchloride; potassium hydroxide; hydrogen; bromine; titanium tetrachloride; potassium carbonate; copper(II) nitrate; copper(II) oxide; sodium nitrite; palladium on activated charcoal; In 1,4-dioxane; pyridine; methanol; tetrachloromethane; dichloromethane; water; acetic anhydride; ethyl acetate; acetone;

upstream raw materials:

sodium methylate

2',4,6,6'-tetramethoxy-3',5-dimethylspiro-3(2H),4'-dione

1,2,3-trimethoxybenzene

2,4,6-trimethoxybenzaldehyde