2,4-dimethoxy-3-methylbenzoic acid

Base Information

• Chemical Name: 2,4-dimethoxy-3-methylbenzoic acid
• CAS No.: 81574-49-4
• Molecular Formula: C₁₀H₁₂O₄
• Molecular Weight: 196.203
• Mol file: 81574-49-4.mol

Synonyms:2,4-dimethoxy-3-methylbenzoic acid

Chemical Property of 2,4-dimethoxy-3-methylbenzoic acid

Chemical Property:

Purity/Quality:

98%min ^*data from raw suppliers

2,4-Dimethoxy-3-methylbenzoic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,4-dimethoxy-3-methylbenzoic acid

There total 14 articles about 2,4-dimethoxy-3-methylbenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.6%

2,4-dimethoxy-3-methylbenzaldehyde (7149-92-0) → 2,4-dimethoxy-3-methylbenzoic acid (81574-49-4)

Guidance literature:

With sodium chlorite; sodium dihydrogenphosphate dihydrate; 2-methyl-but-2-ene; In tert-butyl alcohol; at 0 - 20 ℃; for 1h;

DOI:10.1016/j.ejmech.2021.113333

Reference yield:

2-methylbenzene-1,3-diol (608-25-3) → 2,4-dimethoxy-3-methylbenzoic acid (81574-49-4)

Guidance literature:

Multi-step reaction with 3 steps

1: HCl

2: K₂CO₃ / acetone / Heating

3: m-CPBA / CH₂Cl₂

With hydrogenchloride; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; acetone;

DOI:10.1016/S0040-4039(96)02065-5

Reference yield:

2,4-dihydroxy-3-methylbenzaldehyde (6248-20-0) → 2,4-dimethoxy-3-methylbenzoic acid (81574-49-4)

Guidance literature:

Multi-step reaction with 2 steps

1: K₂CO₃ / acetone / Heating

2: m-CPBA / CH₂Cl₂

With potassium carbonate; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; acetone;

DOI:10.1016/S0040-4039(96)02065-5

upstream raw materials:

3-formyl-2,4-dimethoxy-benzoic acid

2-hydroxy-4-methoxy-3-methylbenzoic acid

dimethyl sulfate

2,4-dimethoxy-3-methylbenzaldehyde

Downstream raw materials:

methyl 2,4-dimethoxy-3-methylbenzoate

C₂₅H₃₄N₂O₇

C₂₅H₃₄N₂O₆

methyl 2,4-dimethoxy-6-(2,4,6-trimethoxy-3-methylphenoxy)-3-methylbenzoate

Refernces

• 1、 Benbow, John W.,Martinez, Bonnie L.. "Biaryl formation using the Suzuki protocol: Considerations of base, halide, and protecting group". . p. 8829 - 8832. Retrieved 2007/10/03.