1-(4-{4-[2-(5-ethylpyridin-2-yl)ethoxy]phenyl}-6-(4-chlorophenyl)pyrimidin-2-yl)-2-phenyl-4-(3,4,5-trimethoxybenzylidene)-1H-imidazol-5(4H)-one

Base Information

• Chemical Name: 1-(4-{4-[2-(5-ethylpyridin-2-yl)ethoxy]phenyl}-6-(4-chlorophenyl)pyrimidin-2-yl)-2-phenyl-4-(3,4,5-trimethoxybenzylidene)-1H-imidazol-5(4H)-one
• CAS No.: 1304143-37-0
• Molecular Formula: C₄₄H₃₈ClN₅O₅
• Molecular Weight: 752.269
• Mol file: 1304143-37-0.mol

Synonyms:

Chemical Property of 1-(4-{4-[2-(5-ethylpyridin-2-yl)ethoxy]phenyl}-6-(4-chlorophenyl)pyrimidin-2-yl)-2-phenyl-4-(3,4,5-trimethoxybenzylidene)-1H-imidazol-5(4H)-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(4-{4-[2-(5-ethylpyridin-2-yl)ethoxy]phenyl}-6-(4-chlorophenyl)pyrimidin-2-yl)-2-phenyl-4-(3,4,5-trimethoxybenzylidene)-1H-imidazol-5(4H)-one

There total 8 articles about 1-(4-{4-[2-(5-ethylpyridin-2-yl)ethoxy]phenyl}-6-(4-chlorophenyl)pyrimidin-2-yl)-2-phenyl-4-(3,4,5-trimethoxybenzylidene)-1H-imidazol-5(4H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

5-Ethyl-2-{[4-(6-(4-chlorophenyl)-2-aminopyrimidin-4-yl)]phenoxyethyl} pyridine (1207094-36-7) + 2-Phenyl-4-(3',4',5'-trimethoxybenzylidene)oxazolone (62616-09-5) → 1-(4-{4-[2-(5-ethylpyridin-2-yl)ethoxy]phenyl}-6-(4-chlorophenyl)pyrimidin-2-yl)-2-phenyl-4-(3,4,5-trimethoxybenzylidene)-1H-imidazol-5(4H)-one (1304143-37-0)

Guidance literature:

With acetic acid; Reflux;

DOI:10.1002/jhet.588

Reference yield:

2-(5-ethyl-pyridin-2-yl)ethyl methanesulfonate (144809-26-7) → 1-(4-{4-[2-(5-ethylpyridin-2-yl)ethoxy]phenyl}-6-(4-chlorophenyl)pyrimidin-2-yl)-2-phenyl-4-(3,4,5-trimethoxybenzylidene)-1H-imidazol-5(4H)-one (1304143-37-0)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium carbonate / ethanol

2: sodium hydroxide / methanol / 20 °C

3: sodium hydroxide / methanol

4: acetic acid / Reflux

With potassium carbonate; acetic acid; sodium hydroxide; In methanol; ethanol;

DOI:10.1002/jhet.588

Reference yield:

Hippuric Acid (495-69-2,140480-84-8,21251-67-2,91787-63-2,66407-11-2) → 1-(4-{4-[2-(5-ethylpyridin-2-yl)ethoxy]phenyl}-6-(4-chlorophenyl)pyrimidin-2-yl)-2-phenyl-4-(3,4,5-trimethoxybenzylidene)-1H-imidazol-5(4H)-one (1304143-37-0)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium acetate / acetic anhydride / 0.25 h / Reflux

2: acetic acid / Reflux

With potassium acetate; acetic acid; In acetic anhydride;

DOI:10.1002/jhet.588

upstream raw materials:

2-(5-ethyl-pyridin-2-yl)ethyl methanesulfonate

Hippuric Acid

5-ethyl-2-(2-hydroxyethyl)pyridine

1-(4-chlorophenyl)-3-{4-[2-(5-ethyl-pyridin-2-yl)-ethoxy]-phenyl}-propen-1-one