(S)-3-Amino-4-(4-amino-3,5-diiodo-phenyl)-butyric acid 2-trimethylsilanyl-ethyl ester

Base Information

Chemical Name:(S)-3-Amino-4-(4-amino-3,5-diiodo-phenyl)-butyric acid 2-trimethylsilanyl-ethyl ester
CAS No.:151291-16-6
Molecular Formula:C₁₅H₂₄I₂N₂O₂Si
Molecular Weight:546.262
Hs Code.:

Synonyms:

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Chemical Property of (S)-3-Amino-4-(4-amino-3,5-diiodo-phenyl)-butyric acid 2-trimethylsilanyl-ethyl ester

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Technology Process of (S)-3-Amino-4-(4-amino-3,5-diiodo-phenyl)-butyric acid 2-trimethylsilanyl-ethyl ester

There total 8 articles about (S)-3-Amino-4-(4-amino-3,5-diiodo-phenyl)-butyric acid 2-trimethylsilanyl-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 949-99-5
4-nitro-3-phenyl-L-alanine

: 151291-16-6
(S)-3-Amino-4-(4-amino-3,5-diiodo-phenyl)-butyric acid 2-trimethylsilanyl-ethyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: aq. NaOH, NaHCO₃ / dioxane / 0 - 20 °C

2: N-methyl morpholine / tetrahydrofuran

3: diethyl ether / 0 - 20 °C

4: silver benzoate, Et₃N

5: 61 percent / H₂ / Pd(OH)2 / ethanol / 2585.7 Torr

6: 74 percent / NaI, chloramine T / acetic acid / 0.75 h / Ambient temperature

7: NaI, chloramine T / acetic acid

8: p-toluenesulfonic acid / CH₂Cl₂ / Ambient temperature

With 4-methyl-morpholine; sodium hydroxide; hydrogen; chloroamine-T; silver benzoate; sodium hydrogencarbonate; toluene-4-sulfonic acid; triethylamine; sodium iodide; palladium dihydroxide; In tetrahydrofuran; 1,4-dioxane; diethyl ether; ethanol; dichloromethane; acetic acid;
DOI:10.1016/0968-0896(96)00185-X

Reference yield:

: 33305-77-0
Boc-Phe(p-NO₂)-OH

: 151291-16-6
(S)-3-Amino-4-(4-amino-3,5-diiodo-phenyl)-butyric acid 2-trimethylsilanyl-ethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: N-methyl morpholine / tetrahydrofuran

2: diethyl ether / 0 - 20 °C

3: silver benzoate, Et₃N

4: 61 percent / H₂ / Pd(OH)2 / ethanol / 2585.7 Torr

5: 74 percent / NaI, chloramine T / acetic acid / 0.75 h / Ambient temperature

6: NaI, chloramine T / acetic acid

7: p-toluenesulfonic acid / CH₂Cl₂ / Ambient temperature

With 4-methyl-morpholine; hydrogen; chloroamine-T; silver benzoate; toluene-4-sulfonic acid; triethylamine; sodium iodide; palladium dihydroxide; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; acetic acid;
DOI:10.1016/0968-0896(96)00185-X

Reference yield:

: C₁₉H₂₆N₂O₈

: 151291-16-6
(S)-3-Amino-4-(4-amino-3,5-diiodo-phenyl)-butyric acid 2-trimethylsilanyl-ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: diethyl ether / 0 - 20 °C

2: silver benzoate, Et₃N

3: 61 percent / H₂ / Pd(OH)2 / ethanol / 2585.7 Torr

4: 74 percent / NaI, chloramine T / acetic acid / 0.75 h / Ambient temperature

5: NaI, chloramine T / acetic acid

6: p-toluenesulfonic acid / CH₂Cl₂ / Ambient temperature

With hydrogen; chloroamine-T; silver benzoate; toluene-4-sulfonic acid; triethylamine; sodium iodide; palladium dihydroxide; In diethyl ether; ethanol; dichloromethane; acetic acid;
DOI:10.1016/0968-0896(96)00185-X