(S)-4-(4-amino-3,5-diiodophenyl)-3-tert-butoxycarbonylaminobutyric acid 2-trimethylsilanyl ethyl ester

Base Information

Chemical Name:(S)-4-(4-amino-3,5-diiodophenyl)-3-tert-butoxycarbonylaminobutyric acid 2-trimethylsilanyl ethyl ester
CAS No.:151291-15-5
Molecular Formula:C₂₀H₃₂I₂N₂O₄Si
Molecular Weight:646.38
Hs Code.:

Synonyms:

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Chemical Property of (S)-4-(4-amino-3,5-diiodophenyl)-3-tert-butoxycarbonylaminobutyric acid 2-trimethylsilanyl ethyl ester

Chemical Property:

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Technology Process of (S)-4-(4-amino-3,5-diiodophenyl)-3-tert-butoxycarbonylaminobutyric acid 2-trimethylsilanyl ethyl ester

There total 6 articles about (S)-4-(4-amino-3,5-diiodophenyl)-3-tert-butoxycarbonylaminobutyric acid 2-trimethylsilanyl ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 949-99-5
4-nitro-3-phenyl-L-alanine

: 151291-15-5
(S)-4-(4-amino-3,5-diiodophenyl)-3-tert-butoxycarbonylaminobutyric acid 2-trimethylsilanyl ethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: aq. NaOH, NaHCO₃ / dioxane / 0 - 20 °C

2: N-methyl morpholine / tetrahydrofuran

3: diethyl ether / 0 - 20 °C

4: silver benzoate, Et₃N

5: 61 percent / H₂ / Pd(OH)2 / ethanol / 2585.7 Torr

6: 74 percent / NaI, chloramine T / acetic acid / 0.75 h / Ambient temperature

7: NaI, chloramine T / acetic acid

With 4-methyl-morpholine; sodium hydroxide; hydrogen; chloroamine-T; silver benzoate; sodium hydrogencarbonate; triethylamine; sodium iodide; palladium dihydroxide; In tetrahydrofuran; 1,4-dioxane; diethyl ether; ethanol; acetic acid;
DOI:10.1016/0968-0896(96)00185-X

Reference yield:

: 33305-77-0
Boc-Phe(p-NO₂)-OH

: 151291-15-5
(S)-4-(4-amino-3,5-diiodophenyl)-3-tert-butoxycarbonylaminobutyric acid 2-trimethylsilanyl ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: N-methyl morpholine / tetrahydrofuran

2: diethyl ether / 0 - 20 °C

3: silver benzoate, Et₃N

4: 61 percent / H₂ / Pd(OH)2 / ethanol / 2585.7 Torr

5: 74 percent / NaI, chloramine T / acetic acid / 0.75 h / Ambient temperature

6: NaI, chloramine T / acetic acid

With 4-methyl-morpholine; hydrogen; chloroamine-T; silver benzoate; triethylamine; sodium iodide; palladium dihydroxide; In tetrahydrofuran; diethyl ether; ethanol; acetic acid;
DOI:10.1016/0968-0896(96)00185-X

Reference yield:

: C₁₉H₂₆N₂O₈

: 151291-15-5
(S)-4-(4-amino-3,5-diiodophenyl)-3-tert-butoxycarbonylaminobutyric acid 2-trimethylsilanyl ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: diethyl ether / 0 - 20 °C

2: silver benzoate, Et₃N

3: 61 percent / H₂ / Pd(OH)2 / ethanol / 2585.7 Torr

4: 74 percent / NaI, chloramine T / acetic acid / 0.75 h / Ambient temperature

5: NaI, chloramine T / acetic acid

With hydrogen; chloroamine-T; silver benzoate; triethylamine; sodium iodide; palladium dihydroxide; In diethyl ether; ethanol; acetic acid;
DOI:10.1016/0968-0896(96)00185-X