<2R-(2α(1S*(2'S*,3a'R*,4'R*,7'R*,7a'R*),2Ξ*),3aα,4β,7β,7aα)>-2,2'-<<2-(Phenylmethoxy)-1-<(phenylmethoxy)methyl>-1,3-propandiyl>bis(oxy)>bis(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran)

Base Information

• Chemical Name: <2R-(2α(1S*(2'S*,3a'R*,4'R*,7'R*,7a'R*),2Ξ*),3aα,4β,7β,7aα)>-2,2'-<<2-(Phenylmethoxy)-1-<(phenylmethoxy)methyl>-1,3-propandiyl>bis(oxy)>bis(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran)
• CAS No.: 120687-01-6
• Molecular Formula: C₄₂H₅₈O₆
• Molecular Weight: 658.919
• Mol file: 120687-01-6.mol

Synonyms:

Chemical Property of <2R-(2α(1S*(2'S*,3a'R*,4'R*,7'R*,7a'R*),2Ξ*),3aα,4β,7β,7aα)>-2,2'-<<2-(Phenylmethoxy)-1-<(phenylmethoxy)methyl>-1,3-propandiyl>bis(oxy)>bis(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of <2R-(2α(1S*(2'S*,3a'R*,4'R*,7'R*,7a'R*),2Ξ*),3aα,4β,7β,7aα)>-2,2'-<<2-(Phenylmethoxy)-1-<(phenylmethoxy)methyl>-1,3-propandiyl>bis(oxy)>bis(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran)

There total 1 articles about <2R-(2α(1S*(2'S*,3a'R*,4'R*,7'R*,7a'R*),2Ξ*),3aα,4β,7β,7aα)>-2,2'-<<2-(Phenylmethoxy)-1-<(phenylmethoxy)methyl>-1,3-propandiyl>bis(oxy)>bis(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzyl bromide (100-39-0) + <2R-(2α(2S*(2'S*,3a'R*,4'R*,7'R*,7a'R*),3Ξ*),3aα,4β,7β,7aα)>-2,4-Bis<(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy>-1,3-butandiol (120686-94-4,120786-22-3,120786-23-4,120786-24-5) → <2R-(2α(1S*(2'S*,3a'R*,4'R*,7'R*,7a'R*),2Ξ*),3aα,4β,7β,7aα)>-2,2'-<<2-(Phenylmethoxy)-1-<(phenylmethoxy)methyl>-1,3-propandiyl>bis(oxy)>bis(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran) (120687-01-6,120786-27-8,120786-28-9)

Guidance literature:

With sodium hydride; Yield given. Multistep reaction; 1) DMF, -15 grad C, 1 h; 2) 2 h, room temp.;

Reference yield: 58.0%

<2R-(2α(1S*(2'S*,3a'R*,4'R*,7'R*,7a'R*),2Ξ*),3aα,4β,7β,7aα)>-2,2'-<<2-(Phenylmethoxy)-1-<(phenylmethoxy)methyl>-1,3-propandiyl>bis(oxy)>bis(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran) (120687-01-6,120786-27-8,120786-28-9) → (2S,2'S-(2α,2'α,3aα,3a'α,4β,4'β,7β,7'β,7aα,7a'α))-2,2'-oxybis[octahydro-7,8,8-trimethyl-4,7-methanobenzofuran] (108031-80-7) + <2R-(2α(Ξ*,S*),3aα,4β,7β,7aα)>-4-<(Octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy>-1,3-bis(phenylmethoxy)-2-butanol (120687-02-7,120786-29-0,120786-30-3)

Guidance literature:

With toluene-4-sulfonic acid; In dichloromethane; for 2h;

Reference yield:

<2R-(2α(1S*(2'S*,3a'R*,4'R*,7'R*,7a'R*),2Ξ*),3aα,4β,7β,7aα)>-2,2'-<<2-(Phenylmethoxy)-1-<(phenylmethoxy)methyl>-1,3-propandiyl>bis(oxy)>bis(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran) (120687-01-6,120786-27-8,120786-28-9) → (1R,2R,4R,6R,7R)-1,10,10-Trimethyl-4-((S)-2,3,4-tris-benzyloxy-butoxy)-3-oxa-tricyclo[5.2.1.02,6]decane (120687-00-5,120786-26-7,120786-31-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 58 percent / p-TsOH / CH₂Cl₂ / 2 h

2: 1) NaH / 1) DMF, -15 grad C, 1 h; 2) room temp., 2 h

With sodium hydride; toluene-4-sulfonic acid; In dichloromethane;

upstream raw materials:

benzyl bromide

<2R-(2α(2S*(2'S*,3a'R*,4'R*,7'R*,7a'R*),3Ξ*),3aα,4β,7β,7aα)>-2,4-Bis<(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy>-1,3-butandiol

Downstream raw materials:

(2S,2'S-(2α,2'α,3aα,3a'α,4β,4'β,7β,7'β,7aα,7a'α))-2,2'-oxybis[octahydro-7,8,8-trimethyl-4,7-methanobenzofuran]

<2R-(2α(Ξ*,S*),3aα,4β,7β,7aα)>-4-<(Octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy>-1,3-bis(phenylmethoxy)-2-butanol

(1R,2R,4R,6R,7R)-1,10,10-Trimethyl-4-((S)-2,3,4-tris-benzyloxy-butoxy)-3-oxa-tricyclo[5.2.1.0^2,6]decane