Technology Process of DB1852
There total 4 articles about DB1852 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1: palladium 10% on activated carbon; hydrogen / ethyl acetate; ethanol / 2587.76 Torr
2: ethanol; acetonitrile / 24 h / 20 °C
With
palladium 10% on activated carbon; hydrogen;
In
ethanol; ethyl acetate; acetonitrile;
DOI:10.1002/cbic.201300622
- Guidance literature:
-
Multi-step reaction with 4 steps
1: potassium tert-butylate / N,N-dimethyl-formamide; tetrahydrofuran
2: tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane
3: palladium 10% on activated carbon; hydrogen / ethyl acetate; ethanol / 2587.76 Torr
4: ethanol; acetonitrile / 24 h / 20 °C
With
tetrakis(triphenylphosphine) palladium(0); palladium 10% on activated carbon; potassium tert-butylate; hydrogen;
In
tetrahydrofuran; 1,4-dioxane; ethanol; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;
2: |Stille Cross Coupling;
DOI:10.1002/cbic.201300622
- Guidance literature:
-
Multi-step reaction with 3 steps
1: tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane
2: palladium 10% on activated carbon; hydrogen / ethyl acetate; ethanol / 2587.76 Torr
3: ethanol; acetonitrile / 24 h / 20 °C
With
tetrakis(triphenylphosphine) palladium(0); palladium 10% on activated carbon; hydrogen;
In
1,4-dioxane; ethanol; ethyl acetate; acetonitrile;
1: |Stille Cross Coupling;
DOI:10.1002/cbic.201300622
