(E)-ethyl pyruvate 2-<2-(methanesulfonyloxy)-3-methyl>phenylhydrazone

Base Information

• Chemical Name: (E)-ethyl pyruvate 2-<2-(methanesulfonyloxy)-3-methyl>phenylhydrazone
• CAS No.: 235758-98-2
• Molecular Formula: C₁₃H₁₈N₂O₅S
• Molecular Weight: 314.362
• Mol file: 235758-98-2.mol

Synonyms:

Chemical Property of (E)-ethyl pyruvate 2-<2-(methanesulfonyloxy)-3-methyl>phenylhydrazone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-ethyl pyruvate 2-<2-(methanesulfonyloxy)-3-methyl>phenylhydrazone

There total 3 articles about (E)-ethyl pyruvate 2-<2-(methanesulfonyloxy)-3-methyl>phenylhydrazone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-acetylpropanoic acid ethyl ester (609-14-3) → (E)-ethyl pyruvate 2-<2-(methanesulfonyloxy)-3-methyl>phenylhydrazone (235758-98-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) conc. aq. HCl, aq. NaNO₂, 2.) 50 percent aq. KOH / 1.) MeCN, 2.) MeCN, EtOH

2: Et₃N / CH₂Cl₂ / 15 h

With hydrogenchloride; potassium hydroxide; triethylamine; sodium nitrite; In dichloromethane;

DOI:10.1248/cpb.47.791

Reference yield:

2-amino-6-methylphenol (17672-22-9) → (E)-ethyl pyruvate 2-<2-(methanesulfonyloxy)-3-methyl>phenylhydrazone (235758-98-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) conc. aq. HCl, aq. NaNO₂, 2.) 50 percent aq. KOH / 1.) MeCN, 2.) MeCN, EtOH

2: Et₃N / CH₂Cl₂ / 15 h

With hydrogenchloride; potassium hydroxide; triethylamine; sodium nitrite; In dichloromethane;

DOI:10.1248/cpb.47.791

Reference yield:

methanesulfonyl chloride (124-63-0) + 2-[(2-hydroxy-3-methyl-phenyl)-hydrazono]-propionic acid ethyl ester → (Z)-ethyl pyruvate 2-<2-(methanesulfonyloxy)-3-methyl>phenylhydrazone + (E)-ethyl pyruvate 2-<2-(methanesulfonyloxy)-3-methyl>phenylhydrazone (235758-98-2)

Guidance literature:

With triethylamine; In dichloromethane; for 15h; Yield given; Yields of byproduct given;

DOI:10.1248/cpb.47.791

upstream raw materials:

methanesulfonyl chloride

2-acetylpropanoic acid ethyl ester

2-amino-6-methylphenol