{(S)-1-[(3aR,4S,6R,6aR)-6-(tert-Butyl-diphenyl-silanyloxy)-2,2-dimethyl-tetrahydro-cyclopenta[1,3]dioxol-4-ylcarbamoyl]-ethyl}-carbamic acid tert-butyl ester

Base Information

Chemical Name:{(S)-1-[(3aR,4S,6R,6aR)-6-(tert-Butyl-diphenyl-silanyloxy)-2,2-dimethyl-tetrahydro-cyclopenta[1,3]dioxol-4-ylcarbamoyl]-ethyl}-carbamic acid tert-butyl ester
CAS No.:160057-25-0
Molecular Formula:C₃₂H₄₆N₂O₆Si
Molecular Weight:582.813
Hs Code.:

{(S)-1-[(3aR,4S,6R,6aR)-6-(tert-Butyl-diphenyl-silanyloxy)-2,2-dimethyl-tetrahydro-cyclopenta[1,3]dioxol-4-ylcarbamoyl]-ethyl}-carbamic acid tert-butyl ester

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Chemical Property of {(S)-1-[(3aR,4S,6R,6aR)-6-(tert-Butyl-diphenyl-silanyloxy)-2,2-dimethyl-tetrahydro-cyclopenta[1,3]dioxol-4-ylcarbamoyl]-ethyl}-carbamic acid tert-butyl ester

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Technology Process of {(S)-1-[(3aR,4S,6R,6aR)-6-(tert-Butyl-diphenyl-silanyloxy)-2,2-dimethyl-tetrahydro-cyclopenta[1,3]dioxol-4-ylcarbamoyl]-ethyl}-carbamic acid tert-butyl ester

There total 9 articles about {(S)-1-[(3aR,4S,6R,6aR)-6-(tert-Butyl-diphenyl-silanyloxy)-2,2-dimethyl-tetrahydro-cyclopenta[1,3]dioxol-4-ylcarbamoyl]-ethyl}-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 77-76-9
2,2-dimethoxy-propane

: 160057-23-8
{(S)-1-[(1S,2R,3R,4R)-4-(tert-Butyl-diphenyl-silanyloxy)-2,3-dihydroxy-cyclopentylcarbamoyl]-ethyl}-carbamic acid tert-butyl ester

: 160057-25-0
{(S)-1-[(3aR,4S,6R,6aR)-6-(tert-Butyl-diphenyl-silanyloxy)-2,2-dimethyl-tetrahydro-cyclopenta[1,3]dioxol-4-ylcarbamoyl]-ethyl}-carbamic acid tert-butyl ester

Guidance literature:: With toluene-4-sulfonic acid; for 1.5h;
DOI:10.1021/jo00095a040

Reference yield:

: 15761-38-3
L-N-Boc-Ala

: 160057-25-0
{(S)-1-[(3aR,4S,6R,6aR)-6-(tert-Butyl-diphenyl-silanyloxy)-2,2-dimethyl-tetrahydro-cyclopenta[1,3]dioxol-4-ylcarbamoyl]-ethyl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: SOCl₂

2: 98 percent / NH₂OH*HCl, KOH / methanol

3: tetrabutylammonium periodate / methanol / 1 h

4: 89 percent / Mo(CO)6 / acetonitrile; H₂O / 3 h / Heating

5: 78 percent / imidazole / dimethylformamide; CH₂Cl₂ / 17 h

6: 85 percent / OsO₄, N-methylmorpholine N-oxide monohydrate / tetrahydrofuran; 2-methyl-propan-2-ol / 13 h

7: 83 percent / p-TsOH*H₂O / 1.5 h

With 1H-imidazole; potassium hydroxide; osmium(VIII) oxide; thionyl chloride; hexacarbonyl molybdenum; hydroxylamine hydrochloride; tetrabutylammonium periodite; toluene-4-sulfonic acid; 4-methylmorpholine N-oxide; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol;
DOI:10.1021/jo00095a040

Reference yield:

: 28875-17-4
(S)-N-(tert-butoxycarbonyl)alanine methyl ester

: 160057-25-0
{(S)-1-[(3aR,4S,6R,6aR)-6-(tert-Butyl-diphenyl-silanyloxy)-2,2-dimethyl-tetrahydro-cyclopenta[1,3]dioxol-4-ylcarbamoyl]-ethyl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 98 percent / NH₂OH*HCl, KOH / methanol

2: tetrabutylammonium periodate / methanol / 1 h

3: 89 percent / Mo(CO)6 / acetonitrile; H₂O / 3 h / Heating

4: 78 percent / imidazole / dimethylformamide; CH₂Cl₂ / 17 h

5: 85 percent / OsO₄, N-methylmorpholine N-oxide monohydrate / tetrahydrofuran; 2-methyl-propan-2-ol / 13 h

6: 83 percent / p-TsOH*H₂O / 1.5 h

With 1H-imidazole; potassium hydroxide; osmium(VIII) oxide; hexacarbonyl molybdenum; hydroxylamine hydrochloride; tetrabutylammonium periodite; toluene-4-sulfonic acid; 4-methylmorpholine N-oxide; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol;
DOI:10.1021/jo00095a040