Technology Process of N-(4-bromobenzoyl)-N'-[3-(5-chloro-1,3-benzoxazol-2-yl)phenyl]thiourea
There total 4 articles about N-(4-bromobenzoyl)-N'-[3-(5-chloro-1,3-benzoxazol-2-yl)phenyl]thiourea which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
ammonium thiocyanate; 4-chlorobenzoyl chloride;
In
acetone;
for 0.333333h;
Inert atmosphere;
Reflux;
3-(5-chlorobenzo[d]oxazol-2-yl)aniline;
In
acetone;
for 1h;
Inert atmosphere;
Reflux;
DOI:10.1016/j.bmcl.2019.05.021
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: palladium 10% on activated carbon; hydrogen / methanol; tetrahydrofuran / 2 h / 2327.23 Torr / Inert atmosphere
2.1: acetone / 0.33 h / Inert atmosphere; Reflux
2.2: 1 h / Inert atmosphere; Reflux
With
palladium 10% on activated carbon; hydrogen;
In
tetrahydrofuran; methanol; acetone;
DOI:10.1016/j.bmcl.2019.05.021
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: triphenylphosphine; trichloroisocyanuric acid / 1,4-dioxane / 0.5 h / 20 °C / Inert atmosphere; Sealed tube; Microwave irradiation
1.2: 0.42 h / 180 °C / Inert atmosphere; Sealed tube; Microwave irradiation
2.1: palladium 10% on activated carbon; hydrogen / methanol; tetrahydrofuran / 2 h / 2327.23 Torr / Inert atmosphere
3.1: acetone / 0.33 h / Inert atmosphere; Reflux
3.2: 1 h / Inert atmosphere; Reflux
With
trichloroisocyanuric acid; palladium 10% on activated carbon; hydrogen; triphenylphosphine;
In
tetrahydrofuran; 1,4-dioxane; methanol; acetone;
DOI:10.1016/j.bmcl.2019.05.021
