cis-4-t-butyl-1-methyl-2-methylenecyclohexanecarboxylic acid

Base Information

• Chemical Name: cis-4-t-butyl-1-methyl-2-methylenecyclohexanecarboxylic acid
• CAS No.: 75646-68-3
• Molecular Formula: C₁₃H₂₂O₂
• Molecular Weight: 210.316
• Mol file: 75646-68-3.mol

Synonyms:

Chemical Property of cis-4-t-butyl-1-methyl-2-methylenecyclohexanecarboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of cis-4-t-butyl-1-methyl-2-methylenecyclohexanecarboxylic acid

There total 16 articles about cis-4-t-butyl-1-methyl-2-methylenecyclohexanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-t-butyl-1-methyl-2-methylenecyclohexabecarbaldehyde (75646-66-1,75646-67-2) → cis-4-t-butyl-1-methyl-2-methylenecyclohexanecarboxylic acid (75646-68-3)

Guidance literature:

With jones reagent; In acetone; at 0.5 ℃; for 1h;

Reference yield:

4-(tert-butyl)cyclohex-1-ene-1-carboxylic acid (67001-73-4,31845-19-9) → cis-4-t-butyl-1-methyl-2-methylenecyclohexanecarboxylic acid (75646-68-3)

Guidance literature:

Multi-step reaction with 13 steps

1: 100 percent / pyridine, oxalyl chloride / benzene / 1 h / Ambient temperature

2: 99 percent / benzene / 18 h / Heating

3: 94 percent / AlCl₃, LiAlH₄ / diethyl ether / 1.) 0 deg C, 1.5 h, 2.) RT, 18 h

4: dimethylsulfoxide / 18 h / 45 °C

5: 92 percent / potassium t-butoxide / tetrahydrofuran / 2 h / -10 °C

6: 30percent oxalic acid / tetrahydrofuran / 0.08 h / Heating

7: KOH / methanol / 4 h / Ambient temperature

8: 95 percent / LiAlH₄ / diethyl ether / 0.75 h / -10 °C

9: 82 percent / PBr₃, pyridine / diethyl ether / 0.5 h

10: light petroleum / 0.25 h / 40 °C

11: 94 percent / potassium t-butoxide / dimethylsulfoxide; tetrahydrofuran / 3 h / -10 °C

12: 98 percent / 30percent oxalic acid / tetrahydrofuran / 0.25 h / Heating

13: Jones reagent / acetone / 1 h / 0.5 °C

With pyridine; potassium hydroxide; lithium aluminium tetrahydride; aluminium trichloride; jones reagent; oxalyl dichloride; potassium tert-butylate; oxalic acid; phosphorus tribromide; In tetrahydrofuran; methanol; diethyl ether; dimethyl sulfoxide; acetone; Petroleum ether; benzene;

Reference yield:

4-t-butyl-1,2,3,4-tetrahydrobenzoic acid (76489-69-5) → cis-4-t-butyl-1-methyl-2-methylenecyclohexanecarboxylic acid (75646-68-3)

Guidance literature:

Multi-step reaction with 14 steps

1: 67 percent / NaOH / H₂O; ethane-1,2-diol / 45 h / Heating

2: 100 percent / pyridine, oxalyl chloride / benzene / 1 h / Ambient temperature

3: 99 percent / benzene / 18 h / Heating

4: 94 percent / AlCl₃, LiAlH₄ / diethyl ether / 1.) 0 deg C, 1.5 h, 2.) RT, 18 h

5: dimethylsulfoxide / 18 h / 45 °C

6: 92 percent / potassium t-butoxide / tetrahydrofuran / 2 h / -10 °C

7: 30percent oxalic acid / tetrahydrofuran / 0.08 h / Heating

8: KOH / methanol / 4 h / Ambient temperature

9: 95 percent / LiAlH₄ / diethyl ether / 0.75 h / -10 °C

10: 82 percent / PBr₃, pyridine / diethyl ether / 0.5 h

11: light petroleum / 0.25 h / 40 °C

12: 94 percent / potassium t-butoxide / dimethylsulfoxide; tetrahydrofuran / 3 h / -10 °C

13: 98 percent / 30percent oxalic acid / tetrahydrofuran / 0.25 h / Heating

14: Jones reagent / acetone / 1 h / 0.5 °C

With pyridine; potassium hydroxide; sodium hydroxide; lithium aluminium tetrahydride; aluminium trichloride; jones reagent; oxalyl dichloride; potassium tert-butylate; oxalic acid; phosphorus tribromide; In tetrahydrofuran; methanol; diethyl ether; water; ethylene glycol; dimethyl sulfoxide; acetone; Petroleum ether; benzene;

upstream raw materials:

4-t-butyl-1-methyl-2-methylenecyclohexabecarbaldehyde

4-(tert-butyl)cyclohex-1-ene-1-carboxylic acid

5-t-butyl-2-methylcyclohexanecarbaldehyde

3-t-butyl-6-methyl-2,3,4,5-tetrahydrobenzaldehyde