Technology Process of 3-t-butyl-6-methyl-2,3,4,5-tetrahydrobenzaldehyde
There total 12 articles about 3-t-butyl-6-methyl-2,3,4,5-tetrahydrobenzaldehyde which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 100 percent / pyridine, oxalyl chloride / benzene / 1 h / Ambient temperature
2: 99 percent / benzene / 18 h / Heating
3: 94 percent / AlCl3, LiAlH4 / diethyl ether / 1.) 0 deg C, 1.5 h, 2.) RT, 18 h
4: dimethylsulfoxide / 18 h / 45 °C
5: 92 percent / potassium t-butoxide / tetrahydrofuran / 2 h / -10 °C
6: 30percent oxalic acid / tetrahydrofuran / 0.08 h / Heating
7: KOH / methanol / 4 h / Ambient temperature
With
pyridine; potassium hydroxide; lithium aluminium tetrahydride; aluminium trichloride; oxalyl dichloride; potassium tert-butylate; oxalic acid;
In
tetrahydrofuran; methanol; diethyl ether; dimethyl sulfoxide; benzene;
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 99 percent / Li / liquid ammonia; diethyl ether / 0.25 h / -70 °C
2: 67 percent / NaOH / H2O; ethane-1,2-diol / 45 h / Heating
3: 100 percent / pyridine, oxalyl chloride / benzene / 1 h / Ambient temperature
4: 99 percent / benzene / 18 h / Heating
5: 94 percent / AlCl3, LiAlH4 / diethyl ether / 1.) 0 deg C, 1.5 h, 2.) RT, 18 h
6: dimethylsulfoxide / 18 h / 45 °C
7: 92 percent / potassium t-butoxide / tetrahydrofuran / 2 h / -10 °C
8: 30percent oxalic acid / tetrahydrofuran / 0.08 h / Heating
9: KOH / methanol / 4 h / Ambient temperature
With
pyridine; potassium hydroxide; sodium hydroxide; lithium aluminium tetrahydride; aluminium trichloride; oxalyl dichloride; potassium tert-butylate; oxalic acid; lithium;
In
tetrahydrofuran; methanol; diethyl ether; ammonia; water; ethylene glycol; dimethyl sulfoxide; benzene;
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 67 percent / NaOH / H2O; ethane-1,2-diol / 45 h / Heating
2: 100 percent / pyridine, oxalyl chloride / benzene / 1 h / Ambient temperature
3: 99 percent / benzene / 18 h / Heating
4: 94 percent / AlCl3, LiAlH4 / diethyl ether / 1.) 0 deg C, 1.5 h, 2.) RT, 18 h
5: dimethylsulfoxide / 18 h / 45 °C
6: 92 percent / potassium t-butoxide / tetrahydrofuran / 2 h / -10 °C
7: 30percent oxalic acid / tetrahydrofuran / 0.08 h / Heating
8: KOH / methanol / 4 h / Ambient temperature
With
pyridine; potassium hydroxide; sodium hydroxide; lithium aluminium tetrahydride; aluminium trichloride; oxalyl dichloride; potassium tert-butylate; oxalic acid;
In
tetrahydrofuran; methanol; diethyl ether; water; ethylene glycol; dimethyl sulfoxide; benzene;
