3-Ethyl-5-[3-(2-methoxycarbonyl-ethyl)-4-methoxycarbonylmethyl-1H-pyrrol-2-ylmethyl]-4-methoxycarbonylmethyl-1H-pyrrole-2-carboxylic acid benzyl ester

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Chemical Name:3-Ethyl-5-[3-(2-methoxycarbonyl-ethyl)-4-methoxycarbonylmethyl-1H-pyrrol-2-ylmethyl]-4-methoxycarbonylmethyl-1H-pyrrole-2-carboxylic acid benzyl ester
CAS No.:87238-30-0
Molecular Formula:C₂₉H₃₄N₂O₈
Molecular Weight:538.598
Hs Code.:

3-Ethyl-5-[3-(2-methoxycarbonyl-ethyl)-4-methoxycarbonylmethyl-1H-pyrrol-2-ylmethyl]-4-methoxycarbonylmethyl-1H-pyrrole-2-carboxylic acid benzyl ester

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Chemical Property of 3-Ethyl-5-[3-(2-methoxycarbonyl-ethyl)-4-methoxycarbonylmethyl-1H-pyrrol-2-ylmethyl]-4-methoxycarbonylmethyl-1H-pyrrole-2-carboxylic acid benzyl ester

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Technology Process of 3-Ethyl-5-[3-(2-methoxycarbonyl-ethyl)-4-methoxycarbonylmethyl-1H-pyrrol-2-ylmethyl]-4-methoxycarbonylmethyl-1H-pyrrole-2-carboxylic acid benzyl ester

There total 7 articles about 3-Ethyl-5-[3-(2-methoxycarbonyl-ethyl)-4-methoxycarbonylmethyl-1H-pyrrol-2-ylmethyl]-4-methoxycarbonylmethyl-1H-pyrrole-2-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4949-45-5
benzyl 2-methylacetoacetate

: 87238-30-0
3-Ethyl-5-[3-(2-methoxycarbonyl-ethyl)-4-methoxycarbonylmethyl-1H-pyrrol-2-ylmethyl]-4-methoxycarbonylmethyl-1H-pyrrole-2-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 1.)isoamyl nitrite 2.)AcOH, NH₄OAc, Zn / 1.)0 degC to room temp. 2.)CCl₄ 90-100 deg C, 3 h

2: 75 percent / Tl(III)nitrate trihydrate, HNO₃ / methanol; CH₂Cl₂ / 24 h / Ambient temperature

3: 87.8 percent / Ac₂O / acetic acid / 0.75 h / 80 °C

4: 1.)p-toluenesulphonic acid 2.)NaBH₄ / 1.)CH₂Cl₂, MeOH 3 h 2.)CH₂Cl₂, MeOH NaBH₄

5: 65 percent / BF₃-etherate / nitromethane / 2 h / -15 °C

6: 1.)p-toluenesulphonic acid 2.)NaBH₄ / 1.)MeOH 15 h, room temp. 2)MeOH

With sodium tetrahydroborate; boron trifluoride diethyl etherate; ammonium acetate; nitric acid; acetic anhydride; toluene-4-sulfonic acid; acetic acid; thallium(III) nitrate; zinc; isopentyl nitrite; In methanol; nitromethane; dichloromethane; acetic acid;
DOI:10.1016/S0040-4020(01)88706-8

Reference yield:

: 87238-27-5
benzyl 4-acetyl-3-ethyl-5-methylpyrrole-2-carboxylate

: 87238-30-0
3-Ethyl-5-[3-(2-methoxycarbonyl-ethyl)-4-methoxycarbonylmethyl-1H-pyrrol-2-ylmethyl]-4-methoxycarbonylmethyl-1H-pyrrole-2-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 75 percent / Tl(III)nitrate trihydrate, HNO₃ / methanol; CH₂Cl₂ / 24 h / Ambient temperature

2: 87.8 percent / Ac₂O / acetic acid / 0.75 h / 80 °C

3: 1.)p-toluenesulphonic acid 2.)NaBH₄ / 1.)CH₂Cl₂, MeOH 3 h 2.)CH₂Cl₂, MeOH NaBH₄

4: 65 percent / BF₃-etherate / nitromethane / 2 h / -15 °C

5: 1.)p-toluenesulphonic acid 2.)NaBH₄ / 1.)MeOH 15 h, room temp. 2)MeOH

With sodium tetrahydroborate; boron trifluoride diethyl etherate; nitric acid; acetic anhydride; toluene-4-sulfonic acid; thallium(III) nitrate; In methanol; nitromethane; dichloromethane; acetic acid;
DOI:10.1016/S0040-4020(01)88706-8

Reference yield:

: 87238-28-6
benzyl 3-ethyl-4-methoxycarbonylmethyl-5-methylpyrrole-2-carboxylate

: 87238-30-0
3-Ethyl-5-[3-(2-methoxycarbonyl-ethyl)-4-methoxycarbonylmethyl-1H-pyrrol-2-ylmethyl]-4-methoxycarbonylmethyl-1H-pyrrole-2-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 87.8 percent / Ac₂O / acetic acid / 0.75 h / 80 °C

2: 1.)p-toluenesulphonic acid 2.)NaBH₄ / 1.)CH₂Cl₂, MeOH 3 h 2.)CH₂Cl₂, MeOH NaBH₄

3: 65 percent / BF₃-etherate / nitromethane / 2 h / -15 °C

4: 1.)p-toluenesulphonic acid 2.)NaBH₄ / 1.)MeOH 15 h, room temp. 2)MeOH

With sodium tetrahydroborate; boron trifluoride diethyl etherate; acetic anhydride; toluene-4-sulfonic acid; In nitromethane; acetic acid;
DOI:10.1016/S0040-4020(01)88706-8