4949-45-5

Upstream product

• 481014-56-6 (±)-benzyl penta-2,3-dienoate 
• 30414-53-0 methyl propanoyl acetate 
• 100-51-6 benzyl alcohol 
• 141-97-9 ethyl acetoacetate 
• 4949-44-4 ethyl propanoylacetate 
• 10467-10-4 ethylmagnesium iodide 
• 14447-18-8 benzyl 2-cyanoacetate 

Downstream Products

• 97189-64-5 benzyl (-)-3-hydroxypentanoate 
• 97189-64-5 benzyl (+)-3-hydroxypentanoate 
• 128773-39-7 2-benzyloxycarbonyl-3-ethyl-5-methyl-pyrrole-4-carboxylic acid 
• 145696-53-3 benzyl-5-t-butoxycarbonyl-3',4-dimethyl-3,4'-diethyl-dipyrrylmethane-5'-carboxylate 
• 56015-18-0 benzyl 5-acetoxymethyl-3-ethyl-4-methylpyrrole-2-carboxylate 
• 61538-85-0 benzyl 3-ethyl-4,5-dimethyl-pyrrole-2-carboxylate 
• 1365386-49-7 cyclohexylmethyl 6-ethyl-4-(3-hydroxyphenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate 
• 1224680-12-9 C₂₆H₃₄N₂O₄Si 
• 1224680-13-0 C₁₉H₂₈N₂O₄Si 
• 1224680-14-1 (S)-4-(3-(tert-butyldimethylsilyloxy)phenyl)-6-ethyl-2-oxo-1,2,3,4-tetrahydropyrimidin-5-carboxylic acid 

Relevant academic research and scientific papers

Oxone-promoted hydration of electron-deficient allenic esters and ketones into 1,3-dicarbonyl compounds

Abstract A novel and mild protocol for the hydration of electron-deficient allenic esters and ketones into various 1,3-dicarbonyl compounds is described. The hydration of allenes promoted by oxone in DMF afforded the corresponding products in moderate to good yields. This work features the employment of only a catalytic amount of inexpensive and nontoxic solid reagent oxone (2KHSO5·KHSO4·K2SO4), avoiding the utility of toxic metals or traditional Br?nsted acids, in a green version of viewpoint. A possible reaction mechanism for this transformation is also primarily proposed.

Synthesis of tetrahydropyridazines by a metal-carbene-directed enantioselective vinylogous N-H insertion/Lewis acid-catalyzed diastereoselective Mannich addition

A versatile cascade of reactions, triggered by RhII-catalyzed diazo decomposition followed by a vinylogous N-H insertion/Lewis acid catalyzed Mannich addition, that produces highly substituted 1,2,3,6-tetrahydropyridazines in up to 97% ee with high yield and diastereocontrol has been developed. Copyright

Layered double hydroxides-supported diisopropylamide: Synthesis, characterization and application in organic reactions

The layered double hydroxides-supported diisopropylamide (LDH-DA) catalyst is found to be an efficient and selective solid base for aldol, Knoevenagel, Henry, Michael, transesterification and epoxidation reactions under liquid phase conditions. LDH-DA is synthesized by the interaction of lithium diisopropylamide with LDH-NO3 (as-synthesized) and calcined LDH-NO3. The LDH-DA (Mg/Al, 3/1) and their precursors are well characterized by using various instrumental techniques such as FT-IR, TGA and DTA, powder XRD, solid state 27Al MAS NMR spectroscopy, SEM and XPS (ESCA).

Dihydropyridine derivative

Dihydropyridine derivatives of the following formula, analogs thereof and pharmaceutically acceptable salts thereof have an activity of selectively inhibiting the action of N-type calcium channel. They are used as remedies for various diseases relating to the N-type calcium channel. STR1

A general synthesis of dioxolenone prodrug moieties

A general method for the synthesis of dioxolenone prodrug moieties from appropriately substituted β-ketoesters is described. This novel and versatile sequence allows for the synthesis of alkyl- or aryl-substituted dioxolenone alcohols 8 or bromides 9. Coupling of the bromides 9 to prepare bis-dioxolenone phosphonate prodrug esters is also presented.

Antibiotic synthesis

A method of preparing intermediates for carbapenem antibiotics characterized by treating a N-deprotected acetoxy conpound of the formula: STR1 in the presence of a Lewis acid or a silylating agent to yeild an intermediate; and cyclizing the intermediate in the presence of rhodium (II) acetate to form a bicyclic ketoester.

BIOCHEMICAL PREPARATIONS OF BOTH THE ENANTIOMERS OF METHYL 3-HYDROXYPENTANOATE AND THEIR CONVERSION TO THE ENANTIOMERS OF 4-HEXANOLIDE, THE PHEROMONE OF TROGODERMA GLABRUM

Both the enantiomers of methyl 3-hydroxypentanoate were prepared by microbial asymmetric reduction of 3-oxopentanoic esters.Conversion of methyl 3-hydroxypentanoate to 4-hexanolide, the pheromone of Trogoderma glabrum, was achieved.