C₅₄H₆₅N₅O₉Si₂

Base Information

• Chemical Name: C₅₄H₆₅N₅O₉Si₂
• CAS No.: 146557-64-4
• Molecular Formula: C₅₄H₆₅N₅O₉Si₂
• Molecular Weight: 984.309
• Mol file: 146557-64-4.mol

Synonyms:

Chemical Property of C₅₄H₆₅N₅O₉Si₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₅₄H₆₅N₅O₉Si₂

There total 3 articles about C₅₄H₆₅N₅O₉Si₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5'-O-(tert-butyldiphenylsilyl)-3'-C-methyleneformyl-3'-deoxythymidine (146557-59-7) → C54H65N5O9Si2 (146557-64-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 60 percent / pyridinium dichromate / dimethylformamide

2: NaOH

3: 1.) N-methylmorpholine, O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate, N-hydroxybenzotriazole, 2.) N-methylmorpholine / 1.) acetonitrile, r.t., 0.5 h, 2.) acetonitrile, r.t., 20 h

With 4-methyl-morpholine; sodium hydroxide; dipyridinium dichromate; benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; In N,N-dimethyl-formamide;

Reference yield:

[(2S,3R,5R)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-acetic acid methyl ester (146557-60-0) → C54H65N5O9Si2 (146557-64-4)

Guidance literature:

Multi-step reaction with 2 steps

1: NaOH

2: 1.) N-methylmorpholine, O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate, N-hydroxybenzotriazole, 2.) N-methylmorpholine / 1.) acetonitrile, r.t., 0.5 h, 2.) acetonitrile, r.t., 20 h

With 4-methyl-morpholine; sodium hydroxide; benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate;

Reference yield:

5'-O-(tert-butyldiphenylsilyl)-3'-C-methylenecarboxylic-3'-deoxythymidine (146557-61-1) + 5'-Amino-3'-tert-butyldiphenylsilyl-5'-deoxythymidine (146557-63-3) → C54H65N5O9Si2 (146557-64-4)

Guidance literature:

With 4-methyl-morpholine; benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; Yield given. Multistep reaction; 1.) acetonitrile, r.t., 0.5 h, 2.) acetonitrile, r.t., 20 h;

upstream raw materials:

5'-O-(tert-butyldiphenylsilyl)-3'-C-methylenecarboxylic-3'-deoxythymidine

5'-Amino-3'-tert-butyldiphenylsilyl-5'-deoxythymidine

5'-O-(tert-butyldiphenylsilyl)-3'-C-methyleneformyl-3'-deoxythymidine

[(2S,3R,5R)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-acetic acid methyl ester