146557-60-0

Basic information

• Product Name: [(2S,3R,5R)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-acetic acid methyl ester
• Synonyms: [(2S,3R,5R)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-acetic acid methyl ester
• CAS NO: 146557-60-0
• Molecular Weight: 536.7
• Mol File: 146557-60-0.mol

Chemical Properties

• CAS DataBase Reference: [(2S,3R,5R)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-acetic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: [(2S,3R,5R)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-acetic acid methyl ester(146557-60-0)
• EPA Substance Registry System: [(2S,3R,5R)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-acetic acid methyl ester(146557-60-0)

Safety Data

• Hazardous Substances Data: 146557-60-0(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 146557-61-1 5'-O-(tert-butyldiphenylsilyl)-3'-C-methylenecarboxylic-3'-deoxythymidine 
• 146557-59-7 5'-O-(tert-butyldiphenylsilyl)-3'-C-methyleneformyl-3'-deoxythymidine 

Downstream Products

• 155135-66-3 C₅₇H₇₁N₅O₉Si₂ 
• 155135-65-2 C₅₅H₆₇N₅O₉Si₂ 
• 146557-64-4 C₅₄H₆₅N₅O₉Si₂ 
• 192564-35-5 C₇₁H₈₁N₇O₁₀Si₂ 
• 192564-33-3 3-Benzyloxymethyl-1-{(2R,4R,5S)-5-(tert-butyl-diphenyl-silanyloxymethyl)-4-[2-oxo-3-(triphenyl-λ⁵-phosphanylidene)-propyl]-tetrahydro-furan-2-yl}-5-methyl-1H-pyrimidine-2,4-dione 
• 222844-65-7 ((2S,3R,5R)-2-({[(4-Methoxy-phenyl)-diphenyl-methyl]-amino}-methyl)-5-{5-methyl-4-[1-methyl-pyrrolidin-(2E)-ylideneamino]-2-oxo-2H-pyrimidin-1-yl}-tetrahydro-furan-3-yl)-acetic acid 
• 222844-57-7 ((2S,3R,5R)-2-({[(4-Methoxy-phenyl)-diphenyl-methyl]-amino}-methyl)-5-{5-methyl-4-[1-methyl-pyrrolidin-(2E)-ylideneamino]-2-oxo-2H-pyrimidin-1-yl}-tetrahydro-furan-3-yl)-acetic acid methyl ester 
• 222844-24-8 [(2S,3R,5R)-2-({[(4-Methoxy-phenyl)-diphenyl-methyl]-amino}-methyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-acetic acid 
• 222844-16-8 [(2S,3R,5R)-2-({[(4-Methoxy-phenyl)-diphenyl-methyl]-amino}-methyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-acetic acid methyl ester 
• 222843-97-2 [(2S,3R,5R)-5-(5-Methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-(toluene-4-sulfonyloxymethyl)-tetrahydro-furan-3-yl]-acetic acid methyl ester 
• 192564-32-2 [(2S,3R,5R)-5-(3-Benzyloxymethyl-5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-furan-3-yl]-acetic acid methyl ester 
• 146557-61-1 5'-O-(tert-butyldiphenylsilyl)-3'-C-methylenecarboxylic-3'-deoxythymidine 

Relevant articles and documents

2'-Deoxyribo-PNAs: A structurally novel class of polyamide nucleic acids with good RNA and DNA binding affinity

2'-Deoxyribo polyamide nucleic acids (2'-deoxyribo-PNAs) 3 are a new class of DNA analogs with a 2',3'-dideoxyribose-polyamide backbone structure. 2'-Deoxyribo-PNAs as well as chimeric oligonucleotide analogs with a mixed DNA / 2'-deoxyribo-PNA structure bind to single stranded complementary nucleic acids with similar affinities as natural DNA.

Replacement of the phosphodiester linkage in oligonucleotides by heterocycles: Synthesis of thymidine dinucleotide analogs with triazole-modified backbones

Novel backbone-modified dinucleotide analogs of types V and VI have been synthesized, where the natural phosphodiester linkage of a T-T dinucleotide has been replaced by a triazole heterocycle. The key step of the synthesis is the regioselective, thermal cycloaddition of a 2-oxoalkylidene triphenylphosphorane with an azide derivative to generate the triazole ring.