3-{2-{3-(2-Methoxycarbonyl-ethyl)-4-methyl-5-[4-methyl-5-oxo-3-vinyl-1,5-dihydro-pyrrol-(2E)-ylidenemethyl]-1H-pyrrol-2-ylmethyl}-4-methyl-5-[3-methyl-5-oxo-4-vinyl-1,5-dihydro-pyrrol-(2E)-ylidenemethyl]-1H-pyrrol-3-yl}-propionic acid

Base Information

• Chemical Name: 3-{2-{3-(2-Methoxycarbonyl-ethyl)-4-methyl-5-[4-methyl-5-oxo-3-vinyl-1,5-dihydro-pyrrol-(2E)-ylidenemethyl]-1H-pyrrol-2-ylmethyl}-4-methyl-5-[3-methyl-5-oxo-4-vinyl-1,5-dihydro-pyrrol-(2E)-ylidenemethyl]-1H-pyrrol-3-yl}-propionic acid
• CAS No.: 72738-52-4
• Molecular Formula: C₃₄H₃₈N₄O₆
• Molecular Weight: 598.699
• Mol file: 72738-52-4.mol

Synonyms:

Chemical Property of 3-{2-{3-(2-Methoxycarbonyl-ethyl)-4-methyl-5-[4-methyl-5-oxo-3-vinyl-1,5-dihydro-pyrrol-(2E)-ylidenemethyl]-1H-pyrrol-2-ylmethyl}-4-methyl-5-[3-methyl-5-oxo-4-vinyl-1,5-dihydro-pyrrol-(2E)-ylidenemethyl]-1H-pyrrol-3-yl}-propionic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-{2-{3-(2-Methoxycarbonyl-ethyl)-4-methyl-5-[4-methyl-5-oxo-3-vinyl-1,5-dihydro-pyrrol-(2E)-ylidenemethyl]-1H-pyrrol-2-ylmethyl}-4-methyl-5-[3-methyl-5-oxo-4-vinyl-1,5-dihydro-pyrrol-(2E)-ylidenemethyl]-1H-pyrrol-3-yl}-propionic acid

There total 8 articles about 3-{2-{3-(2-Methoxycarbonyl-ethyl)-4-methyl-5-[4-methyl-5-oxo-3-vinyl-1,5-dihydro-pyrrol-(2E)-ylidenemethyl]-1H-pyrrol-2-ylmethyl}-4-methyl-5-[3-methyl-5-oxo-4-vinyl-1,5-dihydro-pyrrol-(2E)-ylidenemethyl]-1H-pyrrol-3-yl}-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

bilirubin-IXα bis-tetra-n-butylammonium salt (75494-87-0,107440-18-6) + methyl iodide (74-88-4) → 3-{2-{3-(2-Methoxycarbonyl-ethyl)-4-methyl-5-[4-methyl-5-oxo-3-vinyl-1,5-dihydro-pyrrol-(2Z)-ylidenemethyl]-1H-pyrrol-2-ylmethyl}-4-methyl-5-[3-methyl-5-oxo-4-vinyl-1,5-dihydro-pyrrol-(2Z)-ylidenemethyl]-1H-pyrrol-3-yl}-propionic acid (72738-52-4) + 3-{2-{3-(2-Methoxycarbonyl-ethyl)-4-methyl-5-[3-methyl-5-oxo-4-vinyl-1,5-dihydro-pyrrol-(2Z)-ylidenemethyl]-1H-pyrrol-2-ylmethyl}-4-methyl-5-[4-methyl-5-oxo-3-vinyl-1,5-dihydro-pyrrol-(2Z)-ylidenemethyl]-1H-pyrrol-3-yl}-propionic acid (72738-53-5) + bilirubin dimethylester (19792-68-8)

Guidance literature:

In acetone; for 24h; Yields of byproduct given; Ambient temperature; in the dark;

DOI:10.1016/S0040-4039(00)95907-0

Reference yield: 3.0%

bilirubin-IXα bis-tetra-n-butylammonium salt (75494-87-0,107440-18-6) + methyl p-toluene sulfonate (80-48-8) → 3-{2-{3-(2-Methoxycarbonyl-ethyl)-4-methyl-5-[4-methyl-5-oxo-3-vinyl-1,5-dihydro-pyrrol-(2Z)-ylidenemethyl]-1H-pyrrol-2-ylmethyl}-4-methyl-5-[3-methyl-5-oxo-4-vinyl-1,5-dihydro-pyrrol-(2Z)-ylidenemethyl]-1H-pyrrol-3-yl}-propionic acid (72738-52-4) + 3-{2-{3-(2-Methoxycarbonyl-ethyl)-4-methyl-5-[3-methyl-5-oxo-4-vinyl-1,5-dihydro-pyrrol-(2Z)-ylidenemethyl]-1H-pyrrol-2-ylmethyl}-4-methyl-5-[4-methyl-5-oxo-3-vinyl-1,5-dihydro-pyrrol-(2Z)-ylidenemethyl]-1H-pyrrol-3-yl}-propionic acid (72738-53-5) + bilirubin dimethylester (19792-68-8)

Guidance literature:

In acetone; Yields of byproduct given; Ambient temperature; in the dark;

DOI:10.1016/S0040-4039(00)95907-0

Reference yield:

→ bilirubin dimethyl ester (19792-68-8,71327-45-2,71327-46-3,78856-00-5) + 3-{2-{3-(2-Methoxycarbonyl-ethyl)-4-methyl-5-[4-methyl-5-oxo-3-vinyl-1,5-dihydro-pyrrol-(2E)-ylidenemethyl]-1H-pyrrol-2-ylmethyl}-4-methyl-5-[3-methyl-5-oxo-4-vinyl-1,5-dihydro-pyrrol-(2E)-ylidenemethyl]-1H-pyrrol-3-yl}-propionic acid (72738-52-4) + 3-{2-{3-(2-Methoxycarbonyl-ethyl)-4-methyl-5-[3-methyl-5-oxo-4-vinyl-1,5-dihydro-pyrrol-(2E)-ylidenemethyl]-1H-pyrrol-2-ylmethyl}-4-methyl-5-[4-methyl-5-oxo-3-vinyl-1,5-dihydro-pyrrol-(2E)-ylidenemethyl]-1H-pyrrol-3-yl}-propionic acid (72738-53-5)

Guidance literature:

With sodium hydroxide; In 1,4-dioxane; methanol; Ambient temperature; in the dark;

DOI:10.1016/S0040-4020(01)81666-5

upstream raw materials:

bilirubin-IXα bis-tetra-n-butylammonium salt

methyl p-toluene sulfonate

methyl iodide

cesium salt of bilirubin