2,2-Dimethyl-propionic acid 3-tert-butoxycarbonylmethoxy-4-methoxycarbonylmethyl-5-((3aS,6aR)-2-oxo-tetrahydro-[1,3]dioxolo[4,5-c]pyrrol-5-yl)-benzyl ester

Base Information

Chemical Name:2,2-Dimethyl-propionic acid 3-tert-butoxycarbonylmethoxy-4-methoxycarbonylmethyl-5-((3aS,6aR)-2-oxo-tetrahydro-[1,3]dioxolo[4,5-c]pyrrol-5-yl)-benzyl ester
CAS No.:180412-90-2
Molecular Formula:C₂₆H₃₅NO₁₀
Molecular Weight:521.565
Hs Code.:

2,2-Dimethyl-propionic acid 3-tert-butoxycarbonylmethoxy-4-methoxycarbonylmethyl-5-((3aS,6aR)-2-oxo-tetrahydro-[1,3]dioxolo[4,5-c]pyrrol-5-yl)-benzyl ester

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Chemical Property of 2,2-Dimethyl-propionic acid 3-tert-butoxycarbonylmethoxy-4-methoxycarbonylmethyl-5-((3aS,6aR)-2-oxo-tetrahydro-[1,3]dioxolo[4,5-c]pyrrol-5-yl)-benzyl ester

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Technology Process of 2,2-Dimethyl-propionic acid 3-tert-butoxycarbonylmethoxy-4-methoxycarbonylmethyl-5-((3aS,6aR)-2-oxo-tetrahydro-[1,3]dioxolo[4,5-c]pyrrol-5-yl)-benzyl ester

There total 11 articles about 2,2-Dimethyl-propionic acid 3-tert-butoxycarbonylmethoxy-4-methoxycarbonylmethyl-5-((3aS,6aR)-2-oxo-tetrahydro-[1,3]dioxolo[4,5-c]pyrrol-5-yl)-benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5292-43-3
bromoacetic acid tert-butyl ester

: 180412-90-2
2,2-Dimethyl-propionic acid 3-tert-butoxycarbonylmethoxy-4-methoxycarbonylmethyl-5-((3aS,6aR)-2-oxo-tetrahydro-[1,3]dioxolo[4,5-c]pyrrol-5-yl)-benzyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: K₂CO₃ / acetone

2: pyridine / CH₂Cl₂

3: H₂ / Pd/C / methanol

4: NaHCO₃ / dimethylformamide

5: OsO₄, t-BuOOH, Et₄NOAc / acetone

6: pyridine / CH₂Cl₂

With pyridine; tert.-butylhydroperoxide; osmium(VIII) oxide; tetraethylammonium acetate; hydrogen; sodium hydrogencarbonate; potassium carbonate; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1016/0040-4039(96)01109-4

Reference yield:

: 125229-13-2
3-hydroxy-4-methyl-5-nitrobenzoic acid methyl ester

: 180412-90-2
2,2-Dimethyl-propionic acid 3-tert-butoxycarbonylmethoxy-4-methoxycarbonylmethyl-5-((3aS,6aR)-2-oxo-tetrahydro-[1,3]dioxolo[4,5-c]pyrrol-5-yl)-benzyl ester

Guidance literature:: Multi-step reaction with 11 steps

1: ImH / dimethylformamide

2: NBS, AIBN / benzene

3: DIBAL / CH₂Cl₂ / -78 °C

4: 57 percent / dimethylsulfoxide

5: 59 percent / 1percent H₂SO₄ / methanol / Heating

6: K₂CO₃ / acetone

7: pyridine / CH₂Cl₂

8: H₂ / Pd/C / methanol

9: NaHCO₃ / dimethylformamide

10: OsO₄, t-BuOOH, Et₄NOAc / acetone

11: pyridine / CH₂Cl₂

With pyridine; 1H-imidazole; tert.-butylhydroperoxide; N-Bromosuccinimide; osmium(VIII) oxide; 2,2'-azobis(isobutyronitrile); sulfuric acid; tetraethylammonium acetate; hydrogen; diisobutylaluminium hydride; sodium hydrogencarbonate; potassium carbonate; palladium on activated charcoal; In methanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone; benzene;
DOI:10.1016/0040-4039(96)01109-4

Reference yield:

: 180412-85-5
[4-Bromomethyl-3-(tert-butyl-dimethyl-silanyloxy)-5-nitro-phenyl]-methanol

: 180412-90-2
2,2-Dimethyl-propionic acid 3-tert-butoxycarbonylmethoxy-4-methoxycarbonylmethyl-5-((3aS,6aR)-2-oxo-tetrahydro-[1,3]dioxolo[4,5-c]pyrrol-5-yl)-benzyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 57 percent / dimethylsulfoxide

2: 59 percent / 1percent H₂SO₄ / methanol / Heating

3: K₂CO₃ / acetone

4: pyridine / CH₂Cl₂

5: H₂ / Pd/C / methanol

6: NaHCO₃ / dimethylformamide

7: OsO₄, t-BuOOH, Et₄NOAc / acetone

8: pyridine / CH₂Cl₂

With pyridine; tert.-butylhydroperoxide; osmium(VIII) oxide; sulfuric acid; tetraethylammonium acetate; hydrogen; sodium hydrogencarbonate; potassium carbonate; palladium on activated charcoal; In methanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone;
DOI:10.1016/0040-4039(96)01109-4