2,4-dichloro-N'-(furan-2-ylmethylene)benzohydrazide

Base Information

• Chemical Name: 2,4-dichloro-N'-(furan-2-ylmethylene)benzohydrazide
• CAS No.: 107401-25-2
• Molecular Formula: C₁₂H₈Cl₂N₂O₂
• Molecular Weight: 283.114
• European Community (EC) Number: 659-332-5
• Wikidata: Q76306309
• ChEMBL ID: CHEMBL498901
• Mol file: 107401-25-2.mol

Synonyms:2,4-dichloro-N'-(furan-2-ylmethylene)benzohydrazide;107401-25-2;CHEMBL498901;SCHEMBL13497054;STK391343;AKOS001603902;2,4-dichloro-N'-(2-furylmethylene)benzohydrazide;SR-01000107778;SR-01000107778-1;2,4-dichloro-N'-[(E)-furan-2-ylmethylidene]benzohydrazide;2,4-DICHLORO-N'-[(E)-(FURAN-2-YL)METHYLIDENE]BENZOHYDRAZIDE

Chemical Property of 2,4-dichloro-N'-(furan-2-ylmethylene)benzohydrazide

Chemical Property:

• XLogP3: 3.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 281.9962829
• Heavy Atom Count: 18
• Complexity: 325

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=COC(=C1)C=NNC(=O)C2=C(C=C(C=C2)Cl)Cl
• Isomeric SMILES: C1=COC(=C1)/C=N/NC(=O)C2=C(C=C(C=C2)Cl)Cl

Technology Process of 2,4-dichloro-N'-(furan-2-ylmethylene)benzohydrazide

There total 2 articles about 2,4-dichloro-N'-(furan-2-ylmethylene)benzohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

furfural (98-01-1) + 2,4-dichlorobenzohydrazide (5814-06-2) → 2,4-Dichloro-benzoic acid [1-furan-2-yl-meth-(E)-ylidene]-hydrazide (107401-25-2)

Guidance literature:

In ethanol; for 3h; Heating;

DOI:10.1002/jhet.5570230328

Reference yield:

ethyl 2,4-dichlorobenzoate (56882-52-1) → 2,4-Dichloro-benzoic acid [1-furan-2-yl-meth-(E)-ylidene]-hydrazide (107401-25-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 63 percent / Hydrazine hydrate (99percent) / ethanol / Heating

2: 90 percent / ethanol / 3 h / Heating

With hydrazine hydrate; In ethanol;

DOI:10.1002/jhet.5570230328

Reference yield: 81.0%

2,4-Dichloro-benzoic acid [1-furan-2-yl-meth-(E)-ylidene]-hydrazide (107401-25-2) + mercaptoacetic acid (68-11-1) → 2,4-Dichloro-N-(2-furan-2-yl-4-oxo-thiazolidin-3-yl)-benzamide (130489-73-5)

Guidance literature:

In benzene; for 10h; Heating;

upstream raw materials:

furfural

2,4-dichlorobenzohydrazide

ethyl 2,4-dichlorobenzoate

Downstream raw materials:

2,4-Dichloro-N-(2-furan-2-yl-4-oxo-thiazolidin-3-yl)-benzamide