56882-52-1

Basic information

• Product Name: ETHYL 2,4-DICHLOROBENZOATE
• Synonyms: RARECHEM AL BI 0019;ETHYL 2,4-DICHLOROBENZOATE;Benzoic acid, 2,4-dichloro-, ethyl ester
• CAS NO: 56882-52-1
• Molecular Formula: C₉H₈Cl₂O₂
• Molecular Weight: 219.06
• Mol File: 56882-52-1.mol
• Article Data: 33

Chemical Properties

• Boiling Point: 272.8 °C at 760 mmHg
• Flash Point: 111.8 °C
• Appearance: /
• Density: 1.305 g/cm³
• Vapor Pressure: 0.00595mmHg at 25°C
• Refractive Index: 1.537
• CAS DataBase Reference: ETHYL 2,4-DICHLOROBENZOATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 2,4-DICHLOROBENZOATE(56882-52-1)
• EPA Substance Registry System: ETHYL 2,4-DICHLOROBENZOATE(56882-52-1)

Safety Data

• Hazardous Substances Data: 56882-52-1(Hazardous Substances Data)

Usage

General Description

Ethyl 2,4-dichlorobenzoate is a chemical compound that is often used as a pesticide or herbicide for controlling unwanted plant growth. It is a colorless, crystalline solid with a slightly sweet odor. This chemical is derived from benzoic acid and has two chlorine atoms attached to the benzene ring. It is commonly used in commercial products for agricultural and industrial applications. When applied, ethyl 2,4-dichlorobenzoate acts as a selective herbicide that targets specific types of plants while remaining safe for others. However, it is important to handle this chemical with caution and to follow safety guidelines while using it.

InChI:InChI=1/C9H8Cl2O2/c1-2-13-9(12)7-4-3-6(10)5-8(7)11/h3-5H,2H2,1H3

Upstream product

• 89-75-8 2,4-dichlorobenzoyl chloride 
• 50-84-0 2,4 dichlorobenzoic acid 
• 64-17-5 ethanol 
• 874-42-0 2,4-dichlorobenzaldeyhde 
• 141-52-6 sodium ethanolate 

Downstream Products

• 104517-04-6 2,4-dichloro-1-(prop-1-en-2-yl)benzene 
• 5814-06-2 2,4-dichlorobenzohydrazide 
• 50-84-0 2,4 dichlorobenzoic acid 
• 56882-51-0 5-(2,4-dichlorophenyl)-2,3,5,6-tetrahydroimidazo[2,1-a]isoquinolin-5-ol 
• 35112-28-8 methyl 2,4-dichlorobenzoate 
• 39528-61-5 3-(2',4'-dichlorophenyl)-3-oxopropionitrile 
• 1023279-03-9 3-(2-benzyloxy-4-chlorophenyl)-5-(2,4-dichlorophenyl)-1H-pyrazole 
• 1023279-05-1 3-(2-benzyloxy-4-chlorophenyl)-5-(2,4-dichlorophenyl)-1-decyl-1H-pyrazole 
• 1023279-06-2 5-(2-benzyloxy-4-chlorophenyl)-3-(2,4-dichlorophenyl)-1-decyl-1H-pyrazole 
• 1023279-08-4 5-(2-benzyloxy-4-chlorophenyl)-3-(2,4-dichlorophenyl)-1-dodecyl-1H-pyrazole 
• 1023279-07-3 3-(2-benzyloxy-4-chlorophenyl)-5-(2,4-dichlorophenyl)-1-dodecyl-1H-pyrazole 
• 23288-92-8 2-mercapto-5-(2,4-dichlorophenyl)-1,3,4-oxadiazole 
• 222056-36-2 5-(2,4-dichloro-phenyl)-2-(2,2-diethoxy-ethyl)-2H-pyrazol-3-ylamine 
• 26036-09-9 1-(2,4-dichlorobenzoyl)-3-thiosemicarbazide 

Relevant articles and documents

Synthesis, spectral analysis, antibacterial, antifungal, antioxidant and hemolytic activity studies of some new 2,5-disubstituted-1,3,4-oxadiazoles

Series of 1,3,4-oxadiazole derivatives (5a–5g and 5h, 5i) were synthesized and characterized by FT-IR, 1H NMR, 13C NMR and HR-MS spectral analysis. All the target compounds were screened for their in vitro antibacterial activity against two Gram-negative bacterial strains namely Escherichia coli (MTCC 405) and Salmonella typhi (MTCC 3224) and two Gram-positive bacterial strains namely Bacillus subtilis (MTCC 1790) and Bacillus megaterium (MTCC 1684) and antifungal activity against Aspergillus niger (MTCC 282), Rhizopus oryzae (MTCC 262), Penicillium chrysogenum (MTCC 974), and Candida albicans (MTCC 183) fungal strains. The synthesized compounds exhibited significant antibacterial and antifungal potential. Three compounds (5e, 5f and 5g) have shown higher antibacterial activity with very low MIC values comparable to streptomycin. According to the SAR study, the antibacterial efficacy can be intensified by substituting fluoro and methyl substituents at the para position in acid hydrazide. The synthesized compounds were also screened for % radical scavenging activity by OH and DPPH assay and found to be good antioxidant agents. Besides, the hemolytic study revealed that the synthesized 1,3,4-oxadiazoles possessed negligible cytotoxicity compared with the standard.

Development of Novel (+)-Nootkatone Thioethers Containing 1,3,4-Oxadiazole/Thiadiazole Moieties as Insecticide Candidates against Three Species of Insect Pests

To improve the insecticidal activity of (+)-nootkatone, a series of 42 (+)-nootkatone thioethers containing 1,3,4-oxadiazole/thiadiazole moieties were prepared to evaluate their insecticidal activities against Mythimna separata Walker, Myzus persicae Sulzer, and Plutella xylostella Linnaeus. Insecticidal evaluation revealed that most of the title derivatives exhibited more potent insecticidal activities than the precursor (+)-nootkatone after the introduction of 1,3,4-oxadiazole/thiadiazole on (+)-nootkatone. Among all of the (+)-nootkatone derivatives, compound 8c (1 mg/mL) exhibited the best growth inhibitory (GI) activity against M. separata with a final corrected mortality rate (CMR) of 71.4%, which was 1.54- and 1.43-fold that of (+)-nootkatone and toosendanin, respectively; 8c also displayed the most potent aphicidal activity against M. persicae with an LD50 value of 0.030 μg/larvae, which was closer to that of the commercial insecticidal etoxazole (0.026 μg/larvae); and 8s showed the best larvicidal activity against P. xylostella with an LC50 value of 0.27 mg/mL, which was 3.37-fold that of toosendanin and slightly higher than that of etoxazole (0.28 mg/mL). Furthermore, the control efficacy of 8s against P. xylostella in the pot experiments under greenhouse conditions was better than that of etoxazole. Structure-activity relationships (SARs) revealed that in most cases, the introduction of 1,3,4-oxadiazole/thiadiazole containing halophenyl groups at the C-13 position of (+)-nootkatone could obtain more active derivatives against M. separata, M. persicae, and P. xylostella than those containing other groups. In addition, toxicity assays indicated that these (+)-nootkatone derivatives had good selectivity to insects over nontarget organisms (normal mammalian NRK-52E cells and C. idella and N. denticulata fries) with relatively low toxicity. Therefore, the above results indicate that these (+)-nootkatone derivatives could be further explored as new lead compounds for the development of potential eco-friendly pesticides.

Design and synthesis of new norfloxacin-1,3,4-oxadiazole hybrids as antibacterial agents against methicillin-resistant Staphylococcus aureus (MRSA)

Toward the search of new antibacterial agents to control methicillin-resistant Staphylococcus aureus (MRSA), a class of new norfloxacin-1,3,4-oxadiazole hybrids were designed and synthesized. Antibacterial activities against drug-sensitive bacteria S. aureus and clinical drug resistant isolates of MRSA were evaluated. Compound 5k exhibited excellent antibacterial activities against S. aureus (MIC: 2 μg/mL) and MRSA1–3 (MIC: 0.25–1 μg/mL). The time-kill kinetics demonstrated that compound 5k had an advantage over commonly used antibiotics vancomycin in killing S. aureus and MRSA. Moreover, compound 5k could inhibit the bacteria and destroy their membranes in a short time, and showed very low cytotoxicity to NRK-52E cells. Some interesting structure-activity relationships (SARs) were also discussed. These results indicated that these norfloxacin-1,3,4-oxadiazole hybrids could be further developed into new antibacterial agents against MRSA.