{(1S,2R,3R,5S)-3-[2-Amino-6-chloro-5-(4-chloro-phenylazo)-pyrimidin-4-ylamino]-2-fluoro-5-hydroxymethyl-cyclopentyl}-methanol

Base Information

• Chemical Name: {(1S,2R,3R,5S)-3-[2-Amino-6-chloro-5-(4-chloro-phenylazo)-pyrimidin-4-ylamino]-2-fluoro-5-hydroxymethyl-cyclopentyl}-methanol
• CAS No.: 187877-98-1
• Molecular Formula: C₁₇H₁₉Cl₂FN₆O₂
• Molecular Weight: 429.281
• Mol file: 187877-98-1.mol

Synonyms:

Chemical Property of {(1S,2R,3R,5S)-3-[2-Amino-6-chloro-5-(4-chloro-phenylazo)-pyrimidin-4-ylamino]-2-fluoro-5-hydroxymethyl-cyclopentyl}-methanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of {(1S,2R,3R,5S)-3-[2-Amino-6-chloro-5-(4-chloro-phenylazo)-pyrimidin-4-ylamino]-2-fluoro-5-hydroxymethyl-cyclopentyl}-methanol

There total 3 articles about {(1S,2R,3R,5S)-3-[2-Amino-6-chloro-5-(4-chloro-phenylazo)-pyrimidin-4-ylamino]-2-fluoro-5-hydroxymethyl-cyclopentyl}-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

((1S,2R,3R,5S)-3-Azido-2-fluoro-5-hydroxymethyl-cyclopentyl)-methanol (187877-22-1) → {(1S,2R,3R,5S)-3-[2-Amino-6-chloro-5-(4-chloro-phenylazo)-pyrimidin-4-ylamino]-2-fluoro-5-hydroxymethyl-cyclopentyl}-methanol (187877-98-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 97 percent / hydrogen / Pd-C / ethanol

2: 59 percent / triethylamine / butan-1-ol / 5 h / Heating

3: 1.) hydrochloric acid, sodium nitrite, 2.) acetic acid, sodium acetate / 1.) water, 2.) water, room temperature, overnight

With hydrogenchloride; hydrogen; sodium acetate; acetic acid; triethylamine; sodium nitrite; palladium on activated charcoal; In ethanol; butan-1-ol;

DOI:10.1016/S0040-4020(96)01103-9

Reference yield:

((1S,2R,3R,5S)-3-Amino-2-fluoro-5-hydroxymethyl-cyclopentyl)-methanol (187877-89-0) → {(1S,2R,3R,5S)-3-[2-Amino-6-chloro-5-(4-chloro-phenylazo)-pyrimidin-4-ylamino]-2-fluoro-5-hydroxymethyl-cyclopentyl}-methanol (187877-98-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 59 percent / triethylamine / butan-1-ol / 5 h / Heating

2: 1.) hydrochloric acid, sodium nitrite, 2.) acetic acid, sodium acetate / 1.) water, 2.) water, room temperature, overnight

With hydrogenchloride; sodium acetate; acetic acid; triethylamine; sodium nitrite; In butan-1-ol;

DOI:10.1016/S0040-4020(96)01103-9

Reference yield:

4-chloro-aniline (106-47-8) + [(1S,2R,3R,5S)-3-(2-Amino-6-chloro-pyrimidin-4-ylamino)-2-fluoro-5-hydroxymethyl-cyclopentyl]-methanol (187877-93-6) → {(1S,2R,3R,5S)-3-[2-Amino-6-chloro-5-(4-chloro-phenylazo)-pyrimidin-4-ylamino]-2-fluoro-5-hydroxymethyl-cyclopentyl}-methanol (187877-98-1)

Guidance literature:

With hydrogenchloride; sodium acetate; acetic acid; sodium nitrite; Yield given. Multistep reaction; 1.) water, 2.) water, room temperature, overnight;

DOI:10.1016/S0040-4020(96)01103-9

upstream raw materials:

4-chloro-aniline

[(1S,2R,3R,5S)-3-(2-Amino-6-chloro-pyrimidin-4-ylamino)-2-fluoro-5-hydroxymethyl-cyclopentyl]-methanol

((1S,2R,3R,5S)-3-Amino-2-fluoro-5-hydroxymethyl-cyclopentyl)-methanol

((1S,2R,3R,5S)-3-Azido-2-fluoro-5-hydroxymethyl-cyclopentyl)-methanol