(2S)-3-((5-(2-Methoxycarbonyl-ethyl)-thiophene-2-carbonyl)-amino)-2-(4-trifluoromethylphenyl-sulfonylamino)-propionic Acid tert-Butyl Ester

Base Information

• Chemical Name: (2S)-3-((5-(2-Methoxycarbonyl-ethyl)-thiophene-2-carbonyl)-amino)-2-(4-trifluoromethylphenyl-sulfonylamino)-propionic Acid tert-Butyl Ester
• CAS No.: 250689-00-0
• Molecular Formula: C₂₃H₂₇F₃N₂O₇S₂
• Molecular Weight: 564.604
• Mol file: 250689-00-0.mol

Synonyms:

Chemical Property of (2S)-3-((5-(2-Methoxycarbonyl-ethyl)-thiophene-2-carbonyl)-amino)-2-(4-trifluoromethylphenyl-sulfonylamino)-propionic Acid tert-Butyl Ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S)-3-((5-(2-Methoxycarbonyl-ethyl)-thiophene-2-carbonyl)-amino)-2-(4-trifluoromethylphenyl-sulfonylamino)-propionic Acid tert-Butyl Ester

There total 6 articles about (2S)-3-((5-(2-Methoxycarbonyl-ethyl)-thiophene-2-carbonyl)-amino)-2-(4-trifluoromethylphenyl-sulfonylamino)-propionic Acid tert-Butyl Ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-bromothiophene-2-carboxylic acid (7311-63-9) → (2S)-3-((5-(2-Methoxycarbonyl-ethyl)-thiophene-2-carbonyl)-amino)-2-(4-trifluoromethylphenyl-sulfonylamino)-propionic Acid tert-Butyl Ester (250689-00-0)

Guidance literature:

Multi-step reaction with 5 steps

1: 82 percent / PdCl₂(PPh₂ferrocene)2; Et₃N / acetonitrile / 20 h / 85 °C

2: H₂ / Pd/C / methanol / 7 h / 20 °C

3: 95 percent / TOTU; DIEA / dimethylformamide / 6 h / 20 °C

4: H₂; HCl / Pd/C / methanol / 14 h / 20 °C

With hydrogenchloride; O-[(ethoxycarbonyl)cyanomethyleneamino]-N,N,N',N'-tetramethyluronium tetrafluoroborate; PdCl₂(PPh₂ferrocene)2; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1016/S0960-894X(01)00357-2

Reference yield:

5-(2-methoxycarbonylethyl)thiophene-2-carboxylic acid (250688-80-3) → (2S)-3-((5-(2-Methoxycarbonyl-ethyl)-thiophene-2-carbonyl)-amino)-2-(4-trifluoromethylphenyl-sulfonylamino)-propionic Acid tert-Butyl Ester (250689-00-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 95 percent / TOTU; DIEA / dimethylformamide / 6 h / 20 °C

2: H₂; HCl / Pd/C / methanol / 14 h / 20 °C

With hydrogenchloride; O-[(ethoxycarbonyl)cyanomethyleneamino]-N,N,N',N'-tetramethyluronium tetrafluoroborate; hydrogen; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;

DOI:10.1016/S0960-894X(01)00357-2

Reference yield:

5-(2-methoxycarbonyl-vinyl)-thiophene-2-carboxylic acid (259226-88-5) → (2S)-3-((5-(2-Methoxycarbonyl-ethyl)-thiophene-2-carbonyl)-amino)-2-(4-trifluoromethylphenyl-sulfonylamino)-propionic Acid tert-Butyl Ester (250689-00-0)

Guidance literature:

Multi-step reaction with 4 steps

1: H₂ / Pd/C / methanol / 7 h / 20 °C

2: 95 percent / TOTU; DIEA / dimethylformamide / 6 h / 20 °C

3: H₂; HCl / Pd/C / methanol / 14 h / 20 °C

With hydrogenchloride; O-[(ethoxycarbonyl)cyanomethyleneamino]-N,N,N',N'-tetramethyluronium tetrafluoroborate; hydrogen; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;

DOI:10.1016/S0960-894X(01)00357-2

upstream raw materials:

4-trifluorophenylsulfonyl chloride

2-amino-3-{[5-(2-methoxycarbonyl-ethyl)-thiophene-2-carbonyl]-amino}-propionic acid tert-butyl ester

5-bromothiophene-2-carboxylic acid

5-(2-methoxycarbonylethyl)thiophene-2-carboxylic acid

Downstream raw materials:

(2S)-3-((5-(2-(1,4,5,6-Tetrahydropyrimidin-2-ylcarbamoyl)-ethyl)-thiophene-2-carbonyl)-amino)-2-(4-trifluoromethylphenyl-sulfonylamino)-propionic Acid tert-Butyl Ester