Biotin-PEG2-azide

Base Information

• Chemical Name: Biotin-PEG2-azide
• CAS No.: 1910803-72-3
• Molecular Formula: C₁₆H₂₈N₆O₄S
• Molecular Weight: 400.502
• Mol file: 1910803-72-3.mol

Synonyms:

Chemical Property of Biotin-PEG2-azide

Chemical Property:

Purity/Quality:

99.3% ^*data from raw suppliers

Biotin-PEG2-azide 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Biotin-PEG2-azide

There total 5 articles about Biotin-PEG2-azide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

C2HF3O2*C6H14N4O2 (929537-66-6) + biotin (58-85-5,22879-79-4) → N-(2-(2-(2-azidoethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide (945633-30-7,1910803-72-3)

Guidance literature:

With 2-(7-aza-1H-benzotriazol-1-yl)-1,1,3,3-tetratetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2008.11.003

Reference yield: 75.0%

2-[2-(2-azidoethoxy)ethoxy]ethanamine (166388-57-4) + biotin (58-85-5,22879-79-4) → N-(2-(2-(2-azidoethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide (945633-30-7,1910803-72-3)

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 6h;

DOI:10.1039/c3cc42653j

Reference yield:

2-[2-(2-azidoethoxy)ethoxy]ethanamine (166388-57-4) + C16H19N5O3S → N-(2-(2-(2-azidoethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide (945633-30-7,1910803-72-3)

Guidance literature:

In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1071/CH21049

upstream raw materials:

C₂HF₃O₂*C₆H₁₄N₄O₂

biotin

2-[2-(2-azidoethoxy)ethoxy]ethanamine

1,8-diazido-3,6-dioxaoctane

Refernces

• 1、 -. "Bilateral biotin-phthalocyanine zinc conjugate as well as preparation and application thereof". Paragraph 0014. . Retrieved 2016/12/01.
• 2、 Bhuniya, Sankarprasad,Lee, Min Hee,Jeon, Hyun Mi,Han, Ji Hye,Lee, Jae Hong,Park, Nayoung,Maiti, Sukhendu,Kang, Chulhun,Kim, Jong Seung. "A fluorescence off-on reporter for real time monitoring of gemcitabine delivery to the cancer cells". supporting information. p. 7141 - 7143. Retrieved 2013/08/23.