cis-2-[(1,3-Dihydro-1,3-dioxo-2H-isoindol-2-yl)Methyl]-N-ethyl-1-phenyl cyclopropanecarboxaMide

Base Information

Chemical Name:cis-2-[(1,3-Dihydro-1,3-dioxo-2H-isoindol-2-yl)Methyl]-N-ethyl-1-phenyl cyclopropanecarboxaMide
CAS No.:105310-73-4
Molecular Formula:C₂₁H₂₀N₂O₃
Molecular Weight:348.401
Hs Code.:
Mol file:105310-73-4.mol

Synonyms:(1S,2R)-2-[(1,3-dioxoisoindol-2-yl)methyl]-N-ethyl-1-phenylcyclopropane-1-carboxamide;

Suppliers and Price of cis-2-[(1,3-Dihydro-1,3-dioxo-2H-isoindol-2-yl)Methyl]-N-ethyl-1-phenyl cyclopropanecarboxaMide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
rel-N-Desethyl-N’-phthalimidoMilnacipran
250mg
$ 1760.00

Total 0 raw suppliers

Chemical Property of cis-2-[(1,3-Dihydro-1,3-dioxo-2H-isoindol-2-yl)Methyl]-N-ethyl-1-phenyl cyclopropanecarboxaMide

Chemical Property:

Boiling Point:571.8±29.0 °C(Predicted)
PKA:15.79±0.40(Predicted)
PSA：69.97000
Density:1.296±0.06 g/cm3(Predicted)
LogP:3.15480

Purity/Quality:: rel-N-Desethyl-N’-phthalimidoMilnacipran ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses N-Desethyl-N’-phthalimido Milnacipran is an impurity of Milnacipran (M344600) as potential antidepressant.

Technology Process of cis-2-[(1,3-Dihydro-1,3-dioxo-2H-isoindol-2-yl)Methyl]-N-ethyl-1-phenyl cyclopropanecarboxaMide

There total 4 articles about cis-2-[(1,3-Dihydro-1,3-dioxo-2H-isoindol-2-yl)Methyl]-N-ethyl-1-phenyl cyclopropanecarboxaMide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 69160-63-0
(1S,2R)/(1R,2S)-2-(bromomethyl)-1-phenylcyclopropanecarboxylic acid

: 105310-73-4
(1S,2R)-2-(1,3-Dioxo-1,3-dihydro-isoindol-2-ylmethyl)-1-phenyl-cyclopropanecarboxylic acid ethylamide

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / SOCl₂ / 2 h / Heating

2: diethyl ether / Ambient temperature

3: dimethylformamide / 2.5 h / 110 °C

With thionyl chloride; In diethyl ether; N,N-dimethyl-formamide;
DOI:10.1021/jm00385a013

Reference yield:

: 1074-82-4
potassium phtalimide

: (1R,2S)-2-Bromomethyl-1-phenyl-cyclopropanecarboxylic acid ethylamide

: 105310-73-4
(1S,2R)-2-(1,3-Dioxo-1,3-dihydro-isoindol-2-ylmethyl)-1-phenyl-cyclopropanecarboxylic acid ethylamide

Guidance literature:: In N,N-dimethyl-formamide; at 110 ℃; for 2.5h;
DOI:10.1021/jm00385a013

Reference yield:

: 105310-66-5
(1S,2R)/(1R,2S)-2-(bromomethyl)-1-phenylcyclopropanecarboxylic acid chloride

: 105310-73-4
(1S,2R)-2-(1,3-Dioxo-1,3-dihydro-isoindol-2-ylmethyl)-1-phenyl-cyclopropanecarboxylic acid ethylamide

Guidance literature:: Multi-step reaction with 2 steps

1: diethyl ether / Ambient temperature

2: dimethylformamide / 2.5 h / 110 °C

In diethyl ether; N,N-dimethyl-formamide;
DOI:10.1021/jm00385a013