2-[2-((1S,2S,8aR)-2-Cyano-5,8a-dimethyl-6-oxo-4-phenylselanyl-1,2,3,4,6,7,8,8a-octahydro-naphthalen-1-yl)-2-oxo-ethyl]-malonic acid dimethyl ester

Base Information

Chemical Name:2-[2-((1S,2S,8aR)-2-Cyano-5,8a-dimethyl-6-oxo-4-phenylselanyl-1,2,3,4,6,7,8,8a-octahydro-naphthalen-1-yl)-2-oxo-ethyl]-malonic acid dimethyl ester
CAS No.:134827-27-3
Molecular Formula:C₂₆H₂₉NO₆Se
Molecular Weight:530.479
Hs Code.:

2-[2-((1S,2S,8aR)-2-Cyano-5,8a-dimethyl-6-oxo-4-phenylselanyl-1,2,3,4,6,7,8,8a-octahydro-naphthalen-1-yl)-2-oxo-ethyl]-malonic acid dimethyl ester

Synonyms:

Suppliers and Price of 2-[2-((1S,2S,8aR)-2-Cyano-5,8a-dimethyl-6-oxo-4-phenylselanyl-1,2,3,4,6,7,8,8a-octahydro-naphthalen-1-yl)-2-oxo-ethyl]-malonic acid dimethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-[2-((1S,2S,8aR)-2-Cyano-5,8a-dimethyl-6-oxo-4-phenylselanyl-1,2,3,4,6,7,8,8a-octahydro-naphthalen-1-yl)-2-oxo-ethyl]-malonic acid dimethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-[2-((1S,2S,8aR)-2-Cyano-5,8a-dimethyl-6-oxo-4-phenylselanyl-1,2,3,4,6,7,8,8a-octahydro-naphthalen-1-yl)-2-oxo-ethyl]-malonic acid dimethyl ester

There total 12 articles about 2-[2-((1S,2S,8aR)-2-Cyano-5,8a-dimethyl-6-oxo-4-phenylselanyl-1,2,3,4,6,7,8,8a-octahydro-naphthalen-1-yl)-2-oxo-ethyl]-malonic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 5707-04-0
Phenylselenyl chloride

: 134827-24-0
2-[2-((1R,2R,8aS)-6-Acetoxy-2-cyano-5,8a-dimethyl-1,2,3,7,8,8a-hexahydro-naphthalen-1-yl)-2-oxo-ethyl]-malonic acid dimethyl ester

: 134827-27-3
2-[2-((1S,2S,8aR)-2-Cyano-5,8a-dimethyl-6-oxo-4-phenylselanyl-1,2,3,4,6,7,8,8a-octahydro-naphthalen-1-yl)-2-oxo-ethyl]-malonic acid dimethyl ester

Guidance literature:: With silver trifluoroacetate; for 6h; Ambient temperature;
DOI:10.1139/v91-902

Reference yield:

: 41019-71-0
(+/-)-3,4,8,8a-tetrahydro-5,8a-dimethyl-1,6(2H,7H)-naphthalenedione

: 134827-27-3
2-[2-((1S,2S,8aR)-2-Cyano-5,8a-dimethyl-6-oxo-4-phenylselanyl-1,2,3,4,6,7,8,8a-octahydro-naphthalen-1-yl)-2-oxo-ethyl]-malonic acid dimethyl ester

Guidance literature:: Multi-step reaction with 10 steps

1: 1.) Li, NH₃ / 2.) Et₂O, -78 deg C, 1 h

2: 92 percent / p-toluenesulfonic acid / 18 h

3: 68 percent / 88percent formic acid / 2 h / Heating

4: 82 percent / BF₃*Et₂O / diethyl ether / 18 h

5: 7.07 g / NH₄Cl / dimethylformamide; H₂O / 16 h / 80 °C

6: 80 percent / N-chlorosuccinimide, AgNO₃ / acetonitrile; H₂O / 2 h / Ambient temperature

7: 88 percent / 48percent HBr / 16 h

8: phenyl trimethyl ammonium tribromide / tetrahydrofuran / 0.75 h

9: 1.) NaH / 1.) THF, 2.) THF, 2 h

10: 75 percent / silver trifluoroacetate / 6 h / Ambient temperature

With N-chloro-succinimide; formic acid; boron trifluoride diethyl etherate; ammonia; hydrogen bromide; silver trifluoroacetate; phenyltrimethylammonium tribromide; lithium; sodium hydride; ammonium chloride; toluene-4-sulfonic acid; silver nitrate; In tetrahydrofuran; diethyl ether; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1139/v91-902

Reference yield:

: 1629-58-9
4-penten-3-one

: 134827-27-3
2-[2-((1S,2S,8aR)-2-Cyano-5,8a-dimethyl-6-oxo-4-phenylselanyl-1,2,3,4,6,7,8,8a-octahydro-naphthalen-1-yl)-2-oxo-ethyl]-malonic acid dimethyl ester

Guidance literature:: Multi-step reaction with 12 steps

1: KOH / methanol / 3 h / Heating

2: pyrrolidine / benzene / 24 h / Heating

3: 1.) Li, NH₃ / 2.) Et₂O, -78 deg C, 1 h

4: 92 percent / p-toluenesulfonic acid / 18 h

5: 68 percent / 88percent formic acid / 2 h / Heating

6: 82 percent / BF₃*Et₂O / diethyl ether / 18 h

7: 7.07 g / NH₄Cl / dimethylformamide; H₂O / 16 h / 80 °C

8: 80 percent / N-chlorosuccinimide, AgNO₃ / acetonitrile; H₂O / 2 h / Ambient temperature

9: 88 percent / 48percent HBr / 16 h

10: phenyl trimethyl ammonium tribromide / tetrahydrofuran / 0.75 h

11: 1.) NaH / 1.) THF, 2.) THF, 2 h

12: 75 percent / silver trifluoroacetate / 6 h / Ambient temperature

With pyrrolidine; potassium hydroxide; N-chloro-succinimide; formic acid; boron trifluoride diethyl etherate; ammonia; hydrogen bromide; silver trifluoroacetate; phenyltrimethylammonium tribromide; lithium; sodium hydride; ammonium chloride; toluene-4-sulfonic acid; silver nitrate; In tetrahydrofuran; methanol; diethyl ether; water; N,N-dimethyl-formamide; acetonitrile; benzene;
DOI:10.1139/v91-902