Acetic acid (3S,8R,9S,10R,13S,14S,16S,17S)-3-acetoxy-17-acetyl-10,13-dimethyl-17-methylsulfanylmethoxy-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-16-yl ester

Base Information

• Chemical Name: Acetic acid (3S,8R,9S,10R,13S,14S,16S,17S)-3-acetoxy-17-acetyl-10,13-dimethyl-17-methylsulfanylmethoxy-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-16-yl ester
• CAS No.: 203987-25-1
• Molecular Formula: C₂₇H₄₀O₆S
• Molecular Weight: 492.677
• Mol file: 203987-25-1.mol

Synonyms:

Chemical Property of Acetic acid (3S,8R,9S,10R,13S,14S,16S,17S)-3-acetoxy-17-acetyl-10,13-dimethyl-17-methylsulfanylmethoxy-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-16-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Acetic acid (3S,8R,9S,10R,13S,14S,16S,17S)-3-acetoxy-17-acetyl-10,13-dimethyl-17-methylsulfanylmethoxy-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-16-yl ester

There total 4 articles about Acetic acid (3S,8R,9S,10R,13S,14S,16S,17S)-3-acetoxy-17-acetyl-10,13-dimethyl-17-methylsulfanylmethoxy-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-16-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

3β,16β-diacetoxy-17α-hydroxypregn-5-en-20-one (23357-24-6) + dimethyl sulfoxide (67-68-5,8070-53-9) → Acetic acid (3S,8R,9S,10R,13S,14S,16S,17S)-3-acetoxy-17-acetyl-10,13-dimethyl-17-methylsulfanylmethoxy-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-16-yl ester (203987-25-1)

Guidance literature:

With acetic anhydride;

DOI:10.1016/S0040-4039(97)10814-0

Reference yield:

16-dehydropregnenolone acetate (979-02-2) → Acetic acid (3S,8R,9S,10R,13S,14S,16S,17S)-3-acetoxy-17-acetyl-10,13-dimethyl-17-methylsulfanylmethoxy-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-16-yl ester (203987-25-1)

Guidance literature:

Multi-step reaction with 4 steps

1: H₂O₂/NaOH / methanol

2: pyridine

3: 50 percent / H₂SO₄

4: 60 percent / Ac₂O

With sodium hydroxide; sulfuric acid; dihydrogen peroxide; acetic anhydride; In pyridine; methanol;

DOI:10.1016/S0040-4039(97)10814-0

Reference yield:

3β-hydroxy-16α,17α-epoxypregn-5-en-20-one (974-23-2) → Acetic acid (3S,8R,9S,10R,13S,14S,16S,17S)-3-acetoxy-17-acetyl-10,13-dimethyl-17-methylsulfanylmethoxy-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-16-yl ester (203987-25-1)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine

2: 50 percent / H₂SO₄

3: 60 percent / Ac₂O

With sulfuric acid; acetic anhydride; In pyridine;

DOI:10.1016/S0040-4039(97)10814-0

upstream raw materials:

3β,16β-diacetoxy-17α-hydroxypregn-5-en-20-one

dimethyl sulfoxide

16-dehydropregnenolone acetate

3β-hydroxy-16α,17α-epoxypregn-5-en-20-one