23357-24-6

Upstream product

• 64-19-7 acetic acid 
• 974-23-2 3β-hydroxy-16α,17α-epoxypregn-5-en-20-one 
• 34209-81-9 Acetic acid (3S,8R,9S,10R,13S,14S,16R,17S)-17-acetyl-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-20-oxa-cyclopropa[16,17]cyclopenta[a]phenanthren-3-yl ester 
• 108-24-7 acetic anhydride 
• 979-02-2 16-dehydropregnenolone acetate 

Downstream Products

• 10587-75-4 3beta,16beta-Diacetoxyandrost-5-en-17-one 
• 203987-25-1 Acetic acid (3S,8R,9S,10R,13S,14S,16S,17S)-3-acetoxy-17-acetyl-10,13-dimethyl-17-methylsulfanylmethoxy-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-16-yl ester 
• 1159-66-6 3β,17β-dihydroxyandrost-5-en-16-one 

Relevant academic research and scientific papers

Synthesis of novel 1,2,3-triazolyl derivatives of pregnane, androstane and d-homoandrostane. Tandem "click" reaction/Cu-catalyzed d-homo rearrangement

Copper-catalyzed 1,3-dipolar cycloaddition has been employed in the reaction of steroidal azides with various terminal alkynes. A number of novel 1,2,3-triazolyl derivatives of pregnane, androstane and d-homoandrostane were obtained in high yield (70-98%)

The first synthesis of the aglycone of the potent anti-tumor steroidal saponin OSW-1

The protected aglycone (21e-β) of the potent anti-tumor agent OSW-1 (1) was synthesized in 9 steps from 5-androsten-3β-ol-17-one (10) in 55% overall yield. Key reactions involve ene installation of the side chain, regio and stereoselective dihydroxylation and diastereoselective reduction of the C16 ketone.