23357-24-6Relevant articles and documents
Akhrem et al.
, (1972)
The first synthesis of the aglycone of the potent anti-tumor steroidal saponin OSW-1
Guo, Chuangxing,Fuchs
, p. 1099 - 1102 (2007/10/03)
The protected aglycone (21e-β) of the potent anti-tumor agent OSW-1 (1) was synthesized in 9 steps from 5-androsten-3β-ol-17-one (10) in 55% overall yield. Key reactions involve ene installation of the side chain, regio and stereoselective dihydroxylation and diastereoselective reduction of the C16 ketone.