[4-({[4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-butyl]-[3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propyl]-carbamoyloxy}-methyl)-phenoxy]-acetic acid allyl ester

Base Information

• Chemical Name: [4-({[4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-butyl]-[3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propyl]-carbamoyloxy}-methyl)-phenoxy]-acetic acid allyl ester
• CAS No.: 313983-92-5
• Molecular Formula: C₃₆H₃₅N₃O₉
• Molecular Weight: 653.689
• Mol file: 313983-92-5.mol

Synonyms:

Chemical Property of [4-({[4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-butyl]-[3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propyl]-carbamoyloxy}-methyl)-phenoxy]-acetic acid allyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [4-({[4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-butyl]-[3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propyl]-carbamoyloxy}-methyl)-phenoxy]-acetic acid allyl ester

There total 7 articles about [4-({[4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-butyl]-[3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propyl]-carbamoyloxy}-methyl)-phenoxy]-acetic acid allyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(3-aminopropyl)-1,4-diaminobutane (124-20-9) → [4-({[4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-butyl]-[3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propyl]-carbamoyloxy}-methyl)-phenoxy]-acetic acid allyl ester (313983-92-5)

Guidance literature:

Multi-step reaction with 2 steps

1: CHCl₃

2: NEt₃; DMAP / dimethylformamide

With dmap; triethylamine; In chloroform; N,N-dimethyl-formamide; 1: Acylation / 2: Acylation;

DOI:10.1016/S0960-894X(00)00471-6

Reference yield:

allyl chloroacetate (2916-14-5) → [4-({[4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-butyl]-[3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propyl]-carbamoyloxy}-methyl)-phenoxy]-acetic acid allyl ester (313983-92-5)

Guidance literature:

Multi-step reaction with 4 steps

1: 95 percent / K₂CO₃; KI / acetonitrile

2: 90 percent / aq. NaBH₃CN / tetrahydrofuran

3: 90 percent / pyridine / CH₂Cl₂ / 0 °C

4: NEt₃; DMAP / dimethylformamide

With pyridine; dmap; sodium cyanoborohydride; potassium carbonate; triethylamine; potassium iodide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetonitrile; 1: Alkylation / 2: Reduction / 3: Acylation / 4: Acylation;

DOI:10.1016/S0960-894X(00)00471-6

Reference yield:

N-ethoxycarbonylphthalimide (22509-74-6) → [4-({[4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-butyl]-[3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propyl]-carbamoyloxy}-methyl)-phenoxy]-acetic acid allyl ester (313983-92-5)

Guidance literature:

Multi-step reaction with 2 steps

1: CHCl₃

2: NEt₃; DMAP / dimethylformamide

With dmap; triethylamine; In chloroform; N,N-dimethyl-formamide; 1: Acylation / 2: Acylation;

DOI:10.1016/S0960-894X(00)00471-6

upstream raw materials:

N¹,N¹⁰-bisphthaloylspermidine

4-nitrophenyl-4'-hydroxymethylphenyl-1'-oxyallylacetate carbonate

N-(3-aminopropyl)-1,4-diaminobutane

allyl chloroacetate

Downstream raw materials:

N¹,N⁸-bis(dihydrocaffeoyl)spermidine

[4-({[4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-butyl]-[3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propyl]-carbamoyloxy}-methyl)-phenoxy]-acetic acid