4-{4-[(S)-2-((S)-1-Benzyloxycarbonyl-3-methyl-butylcarbamoyl)-2-((S)-4-tert-butoxycarbonyl-2-tert-butoxycarbonylamino-butyrylamino)-ethyl]-phenoxysulfonyl}-2-hydroxy-benzoic acid

Base Information

Chemical Name:4-{4-[(S)-2-((S)-1-Benzyloxycarbonyl-3-methyl-butylcarbamoyl)-2-((S)-4-tert-butoxycarbonyl-2-tert-butoxycarbonylamino-butyrylamino)-ethyl]-phenoxysulfonyl}-2-hydroxy-benzoic acid
CAS No.:192052-62-3
Molecular Formula:C₄₃H₅₅N₃O₁₄S
Molecular Weight:869.987
Hs Code.:

4-{4-[(S)-2-((S)-1-Benzyloxycarbonyl-3-methyl-butylcarbamoyl)-2-((S)-4-tert-butoxycarbonyl-2-tert-butoxycarbonylamino-butyrylamino)-ethyl]-phenoxysulfonyl}-2-hydroxy-benzoic acid

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Chemical Property of 4-{4-[(S)-2-((S)-1-Benzyloxycarbonyl-3-methyl-butylcarbamoyl)-2-((S)-4-tert-butoxycarbonyl-2-tert-butoxycarbonylamino-butyrylamino)-ethyl]-phenoxysulfonyl}-2-hydroxy-benzoic acid

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Technology Process of 4-{4-[(S)-2-((S)-1-Benzyloxycarbonyl-3-methyl-butylcarbamoyl)-2-((S)-4-tert-butoxycarbonyl-2-tert-butoxycarbonylamino-butyrylamino)-ethyl]-phenoxysulfonyl}-2-hydroxy-benzoic acid

There total 3 articles about 4-{4-[(S)-2-((S)-1-Benzyloxycarbonyl-3-methyl-butylcarbamoyl)-2-((S)-4-tert-butoxycarbonyl-2-tert-butoxycarbonylamino-butyrylamino)-ethyl]-phenoxysulfonyl}-2-hydroxy-benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: (tert-butyl)dimethylsilyl 2-[(tert-butyl)dimethylsilyloxy]-4-(chlorosulfonyl)benzoate

: 192052-54-3
(S)-2-[(S)-2-((S)-4-tert-Butoxycarbonyl-2-tert-butoxycarbonylamino-butyrylamino)-3-(4-hydroxy-phenyl)-propionylamino]-4-methyl-pentanoic acid benzyl ester

: 192052-62-3
4-{4-[(S)-2-((S)-1-Benzyloxycarbonyl-3-methyl-butylcarbamoyl)-2-((S)-4-tert-butoxycarbonyl-2-tert-butoxycarbonylamino-butyrylamino)-ethyl]-phenoxysulfonyl}-2-hydroxy-benzoic acid

: C₄₉H₆₉N₃O₁₄SSi

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 20h; Ambient temperature; 1.) -3 deg C;
DOI:10.1002/hlca.19970800304

Reference yield:

: 32886-55-8
(S)-5-tert-butyl 1-(2,5-dioxopyrrolidin-1-yl) 2-((tert-butoxycarbonyl)amino)pentanedioate

: 192052-62-3
4-{4-[(S)-2-((S)-1-Benzyloxycarbonyl-3-methyl-butylcarbamoyl)-2-((S)-4-tert-butoxycarbonyl-2-tert-butoxycarbonylamino-butyrylamino)-ethyl]-phenoxysulfonyl}-2-hydroxy-benzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 94 percent / (ⁱPr)2EtN / dimethylformamide / 23 h / Ambient temperature

2: 9 percent / (ⁱPr)Et₂N / CH₂Cl₂ / 20 h / Ambient temperature; 1.) -3 deg C

With N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/hlca.19970800304

Reference yield:

: 114658-52-5
N-L-tyrosyl-L-leucine benzyl ester; hydrochloride

: 192052-62-3
4-{4-[(S)-2-((S)-1-Benzyloxycarbonyl-3-methyl-butylcarbamoyl)-2-((S)-4-tert-butoxycarbonyl-2-tert-butoxycarbonylamino-butyrylamino)-ethyl]-phenoxysulfonyl}-2-hydroxy-benzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 94 percent / (ⁱPr)2EtN / dimethylformamide / 23 h / Ambient temperature

2: 9 percent / (ⁱPr)Et₂N / CH₂Cl₂ / 20 h / Ambient temperature; 1.) -3 deg C

With N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/hlca.19970800304